Synthesis cum characterization of MgO and MnO nanoparticles and their assessment as antidiabetic and antioxidative agents in diabetic rat model

Magnesium oxide (MgO) and manganese oxide (MnO) nanoparticles were synthesized by chemical method and characterized. Their antioxidative and antidiabetic potential was assessed. Seven groups with eight rats per group were assigned as negative control (NC), positive control (PC), standard control (Std-C), magnesium oxide nanoparticle high dose (MgO-300) and low dose (MgO-150), manganese oxide nanoparticle high dose (MnO-30) and low dose (MnO-15) groups. Glucose levels showed an increase in PC group whereas MgO-300 group showed a maximal decrease in glucose levels (P < 0.05). Insulin levels increased significantly in MgO-300 group as compared with PC group. The MnO-30 and MnO-15 groups showed a dose-dependent effect (P < 0.05). A significant increase in serum paraoxonase was observed in the MgO-300 group (P < 0.05). Total antioxidant capacity (TAC) and total oxidant status (TOS) indicated a significant effect exerted by MgO-300 and MgO-150 groups (P < 0.05). MgO and MnO nanoparticles can potentially be an alternative for bulk supplementation for Diabetes Mellitus mangement.