Reversal of synaptic vesicle docking at central synapses

被引：186
|
作者：
Murthy, VN
Stevens, CF
机构：
[1] Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA
[2] Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA
来源：
NATURE NEUROSCIENCE | 1999年 / 2卷 / 06期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/9149
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We used quantitative fluorescence imaging of vesicles labeled with membrane-soluble dyes to determine rates of undocking and spontaneous exocytosis of vesicles docked to the active zone of hippocampal synapses in culture. Individual vesicles undock about once per two minutes and spontaneously exocytose about once per eight minutes. Thus, not only does undocking occur, but it is over threefold faster than spontaneous fusion.
引用
收藏
页码：503 / 507
页数：5
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