FHL2 Regulates Natural Killer Cell Development and Activation during Streptococcus pneumoniae Infection

被引：18

作者：

Baranek, Thomas ^{[1
,2
]}

Morello, Eric ^{[1
,2
]}

Valayer, Alexandre ^{[1
,2
]}

Aimar, Rose-France ^{[1
,2
]}

Brea, Deborah ^{[1
,2
]}

Henry, Clemence ^{[1
,2
]}

Besnard, Anne-Gaelle ^{[1
,2
]}

Dalloneau, Emilie ^{[1
,2
]}

Guillon, Antoine ^{[1
,2
,3
]}

Dequin, Pierre-Francois ^{[1
,2
,3
]}

Narni-Mancinelli, Emilie ^{[4
]}

Vivier, Eric ^{[4
,5
]}

Laurent, Fabrice ^{[6
]}

Wei, Yu ^{[7
]}

Paget, Christophe ^{[1
,2
]}

Si-Tahar, Mustapha ^{[1
,2
]}

机构：

[1] INSERM, CEPR, UMR 1100, Tours, France

[2] Univ Tours, Tours, France

[3] Ctr Hosp Reg Univ, Serv Reanimat Polyvalente, Tours, France

[4] Aix Marseille Univ, CNRS, Ctr Immunol Marseille Luminy, INSERM, Marseille, France

[5] Hop La Timone, AP HM, Marseille, France

[6] Univ Tours, ISP, INRA, Nouzilly, France

[7] Inst Pasteur, Hepacivirus & Immunite Innee, Paris, France

来源：

FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷

关键词：

NK cell; maturation; FHL2; transcriptional factor; pneumococcal infections; mouse models; NK CELLS; IFN-GAMMA; NEUTROPHIL RECRUITMENT; INTERFERON-GAMMA; PROTECTIVE ROLE; HOST-DEFENSE; EXPRESSION; LUNG; RECEPTOR; MUSCLE;

D O I：

10.3389/fimmu.2017.00123

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent in silico studies suggested that the transcription cofactor LIM-only protein FHL2 is a major transcriptional regulator of mouse natural killer (NK) cells. However, the expression and role of FHL2 in NK cell biology are unknown. Here, we confirm that FHL2 is expressed in both mouse and human NK cells. Using FHL2(-/-) mice, we found that FHL2 controls NK cell development in the bone marrow and maturation in peripheral organs. To evaluate the importance of FHL2 in NK cell activation, FHL2(-/-) mice were infected with Streptococcus pneumoniae. FHL2(-/-) mice are highly susceptible to this infection. The activation of lung NK cells is altered in FHL2(-/-) mice, leading to decreased IFN. production and a loss of control of bacterial burden. Collectively, our data reveal that FHL2 is a new transcription cofactor implicated in NK cell development and activation during pulmonary bacterial infection.

引用

页数：12

共 59 条

[1] The LIM-Only Protein FHL2 Attenuates Lung Inflammation during Bleomycin-Induced Fibrosis [J].