N-Fmoc-aminooxy-2-chlorotrityl polystyrene resin: A facile solid-phase methodology for the synthesis of hydroxamic acids

被引：79

作者：

Mellor, SL

McGuire, C

Chan, WC

机构：

[1] Dept. of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(97)00594-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using the new compound N-Fmoc-hydroxylamine 1 we have generated a facile route to a high loading, acid labile solid-phase resin bearing a hydroxylamine linker. The novel N-Fmoc-aminooxy-2-chlorotrityl polystyrene 2 showed generic utility for the construction of hydroxamic acids, including peptidyl hydroxamic acids. (C) 1997 Elsevier Science Ltd.

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页码：3311 / 3314

页数：4

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