Immunogenetics of nasopharyngeal carcinoma

被引：3

作者：

Ben Chaaben, Arij ^{[1
,2
,3
]}

Abaza, Hajer ^{[1
]}

Douik, Hayet ^{[1
]}

Harzallah, Latifa ^{[1
]}

Charron, Dominique ^{[2
,3
]}

Krishnamoorthy, Rajagopal ^{[2
,3
]}

Guemira, Fethi ^{[1
]}

Tamouza, Ryad ^{[2
,3
]}

机构：

[1] Inst Salah Azaiz, Lab Biol Clin, Tunis, Tunisia

[2] Hop St Louis, Inserm U940, AP HP, Lab Jean Dausset Immunol & Histocompatibil,CIB HO, Paris, France

[3] Hop St Louis, Inserm U940, IUH, Paris, France

来源：

ANNALES DE BIOLOGIE CLINIQUE | 2014年 / 72卷 / 03期

关键词：

nasopharyngeal carcinoma; immuno genetics; inflammation; anti-tumor; surveillance; CANCER-RISK; GENETIC POLYMORPHISMS; UNDIFFERENTIATED CARCINOMA; DISTINCT EXPRESSION; ASSOCIATION; TUMOR; SUSCEPTIBILITY; HLA; VARIANTS; ANTIGENS;

D O I：

10.1684/abc.2014.0958

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder. involving both genetic and environmental factors. Genetic predisposition linked to the immune system has been associated with various tumors. This involves genetic diversity of the genes encoding the molecules of the immune response such as inflammation and anti-tumor surveillance. In this work, we examined the impact of the immunogenetic diversity on the risk of the NPC in different populations studied. These data show that the interindividual variability of the genetic regulation of immune processes increases the risk of NPC in individuals previously predisposed due to other risk factors (genetic/environmental). This synthesis, in addition to the predictive aspects, could provide innovative research for the development of new therapeutic approaches.

引用

页码：281 / 291

页数：11

共 86 条

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ABLASHI DV, 1981, CANCER RES, V41, P2014

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