Scar and pulmonary expression and shedding of ACE in rat myocardial infarction

被引：17

作者：

Gaertner, R ^{[1
]}

Prunier, F ^{[1
]}

Philippe, M ^{[1
]}

Louedec, L ^{[1
]}

Mercadier, JJ ^{[1
]}

Michel, JB ^{[1
]}

机构：

[1] CHU Xavier Bichat, INSERM, U460, Dept Cardiovasc Res, F-75018 Paris, France

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2002年 / 283卷 / 01期

关键词：

experimental heart failure; cardiac remodeling;

D O I：

10.1152/ajpheart.00848.2001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined the topology of angiotensin-converting enzyme (ACE) mRNA expression, activity, and shedding in myocardial infarction-induced heart failure and sought to elucidate the source of the increased plasma ACE activity in this model. Three months after coronary ligature, lung, scar, and remaining viable left ventricular tissues were analyzed for ACE mRNA expression as well as tissue and solubilized ACE activity. ACE mRNA expression increased in the scar with respect to infarct severity, decreased in the lung, and remained unchanged in the left ventricle. ACE activity decreased in the lung and increased in the scar tissue and plasma. Shedding of ACE remained constant in the lung and increased in the scar. This study shows that ACE expression and activity is shifted from the pulmonary endothelium to the infarct scar tissue and that constancy of shedding in the lung and its increase in the scar are the source of the increased plasma ACE in congestive heart failure.

引用

页码：H156 / H164

页数：9

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