NEURON - GLIA INTERACTIONS - OPINION The bright side of the glial scar in CNS repair

被引：515
作者：
Rolls, Asya [1 ]
Shechter, Ravid [1 ]
Schwartz, Michal [1 ]
机构：
[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel
来源：
NATURE REVIEWS NEUROSCIENCE | 2009年 / 10卷 / 03期
关键词：
SPINAL-CORD-INJURY; CHONDROITIN SULFATE PROTEOGLYCAN; MYELIN-ASSOCIATED GLYCOPROTEIN; PROMOTES FUNCTIONAL RECOVERY; REACTIVE ASTROCYTES; NEURITE OUTGROWTH; AXONAL REGENERATION; CELL-PROLIFERATION; SENSORY AXONS; TENASCIN-C;
D O I：
10.1038/nrn2591
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Following CNS injury, in an apparently counterintuitive response, scar tissue formation inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar-modulating treatments have become a leading therapeutic goal in the field of spinal cord injury. However, increasing evidence suggests a beneficial role for this scar tissue as part of the endogenous local immune regulation and repair process. How can these opposing effects be reconciled? Perhaps it is all a matter of timing.
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收藏
页码：235 / U91
页数：7
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