NEURON - GLIA INTERACTIONS - OPINION The bright side of the glial scar in CNS repair

被引：525

作者：

Rolls, Asya ^{[1
]}

Shechter, Ravid ^{[1
]}

Schwartz, Michal ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

来源：

NATURE REVIEWS NEUROSCIENCE | 2009年 / 10卷 / 03期

关键词：

SPINAL-CORD-INJURY; CHONDROITIN SULFATE PROTEOGLYCAN; MYELIN-ASSOCIATED GLYCOPROTEIN; PROMOTES FUNCTIONAL RECOVERY; REACTIVE ASTROCYTES; NEURITE OUTGROWTH; AXONAL REGENERATION; CELL-PROLIFERATION; SENSORY AXONS; TENASCIN-C;

D O I：

10.1038/nrn2591

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Following CNS injury, in an apparently counterintuitive response, scar tissue formation inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar-modulating treatments have become a leading therapeutic goal in the field of spinal cord injury. However, increasing evidence suggests a beneficial role for this scar tissue as part of the endogenous local immune regulation and repair process. How can these opposing effects be reconciled? Perhaps it is all a matter of timing.

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页码：235 / U91

页数：7

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