Sphingosine 1-phosphate: A Potential Molecular Target for Ovarian Cancer Therapy?

被引：29

作者：

Dai, Lan ^{[1
,2
]}

Xia, Pu ^{[3
]}

Di, Wen ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Renji Hosp, Dept Obstet & Gynecol, Sch Med, Shanghai 200127, Peoples R China

[2] Fudan Univ, Focus Construct Subject Shanghai Educ Dept, Shanghai Key Lab Gynecol Oncol, Shanghai 200433, Peoples R China

[3] Fudan Univ, Zhongshan Hosp, Dept Endocrinol, Shanghai 200433, Peoples R China

来源：

CANCER INVESTIGATION | 2014年 / 32卷 / 03期

关键词：

Ovarian cancer; Sphingosine; 1-phosphate; Sphingosine kinase; ENDOTHELIAL GROWTH-FACTOR; SMOOTH-MUSCLE-CELLS; NECROSIS-FACTOR-ALPHA; UP-REGULATION; TNF-ALPHA; KINASE; SPHINGOSINE-1-PHOSPHATE LYASE; SIGNALING PATHWAY; PROSTATE-CANCER; DOWN-REGULATION;

D O I：

10.3109/07357907.2013.876646

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sphingosine 1-phosphate (S1P) is an important signaling regulator involved in tumor progression in multiple neoplasms. However, the role of S1P in the pathogenesis of ovarian cancer remains unclear. Herein, we summarize recent advances in understanding the impact of S1P signaling in ovarian cancer progression. S1P, aberrantly produced in ovarian cancer patients, is involved in the regulation of key cellular processes that contribute to ovarian cancer initiation and progression. Moreover, agents that block the S1P signaling pathway inhibit ovarian cancer cell growth or induce apoptosis. Hence, current evidence suggests that S1P may become a potential molecular target for ovarian cancer therapy.

引用

页码：71 / 80

页数：10

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