Evaluation of acetylcholinesterase inhibitory activity of Brazilian red macroalgae organic extracts

被引：19

作者：

Machado, Levi P. ^{[1
]}

Carvalho, Luciana R. ^{[1
]}

Young, Maria Claudia M. ^{[2
]}

Cardoso-Lopes, Elaine M. ^{[3
]}

Centeno, Danilo C. ^{[4
]}

Zambotti-Villela, Leonardo ^{[5
]}

Colepicolo, Pio ^{[5
]}

Yokoya, Nair S. ^{[1
]}

机构：

[1] Inst Bot, Nucleo Pesquisa Ficol, Sao Paulo, SP, Brazil

[2] Inst Bot, Nucleo Pesquisa Ficol & Bioquim, Sao Paulo, SP, Brazil

[3] Univ Nove Julho, Dept Farmacia, Sao Paulo, SP, Brazil

[4] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Sao Paulo, SP, Brazil

[5] Univ Sao Paulo, Inst Quim, Sao Paulo, SP, Brazil

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2015年 / 25卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

Acetylcholinesterase inhibition; Halogenated monoterpenes; Hypnea; Ochtodes; Pterocladiella; Rhodophyta; HALOGENATED MONOTERPENE PRODUCTION; OCHTODES-SECUNDIRAMEA RHODOPHYTA; TROPICAL MARINE-ALGAE; CHEMICAL-ANALYSIS; MICROPLANTLETS; GIGARTINALES;

D O I：

10.1016/j.bjp.2015.09.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Alzheimer's disease affects nearly 36.5 million people worldwide, and acetylcholinesterase inhibition is currently considered the Main therapeutic strategy against it. Seaweed biodiversity in Brazil represents one of the most important sources of-biologically active Compounds for applications in phytotherapy. Accordingly, this study aimed to carry out a quantitative and qualitative assessment, of Hypnea musciformis (Wulfen) J.V. Lamouroux, Ochtodes secundiramea (Montagne) M.A. Howe, and Pterocladiella capillacea (S.G. Gmelin) Santelices & Hommersand (Rhodophyta) in order to determine the AChE effects from their extracts. As a matter of fact, the O. secundiramea extract showed 48% acetylcholinesterase inhibition at 400 mu g/ml. The chemical composition of the bioactive fraction was determined by gas chromatography-mass spectrometry (GC-MS); this fraction is solely composed of halogenated monoterpenes, therefore allowing assignment of acetylcholinesterase inhibition activity to them. 2015 (C) Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.

引用

页码：657 / 662

页数：6

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