Cisplatin-Induced Gastric Dysrhythmia and Emesis in Dogs and Possible Role of Gastric Electrical Stimulation

被引：16

作者：

Yu, Xiaoyun ^{[1
]}

Yang, Jie ^{[1
]}

Hou, Xiaohua ^{[1
]}

Zhang, Kan ^{[1
]}

Qian, Wei ^{[1
]}

Chen, J. D. Z. ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Div Gastroenterol, Tongji Med Coll, Wuhan 430022, Peoples R China

[2] Univ Texas Med Branch, Div Gastroenterol, GI Res, Galveston, TX 77555 USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2009年 / 54卷 / 05期

关键词：

Chemotherapy; Dysrhythmia; Gastric electrical stimulation; Gastric motility; Gastric slow waves; Nausea and vomiting; MYOELECTRIC ACTIVITY; DELAYED EMESIS; SHORT PULSES; GASTROPARESIS; ONDANSETRON; RATS; DEXAMETHASONE; VASOPRESSIN; PARAMETERS; RESPONSES;

D O I：

10.1007/s10620-008-0470-0

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The aim of this study was to investigate the effect of cisplatin on gastric myoelectrical activity and the role of gastric electrical stimulation in the treatment of cisplatin-induced emesis in dogs. Seven dogs implanted with electrodes on the gastric serosa were used in a two-session study. Cisplatin was infused in both the control session and the gastric electrical stimulation session, and gastric electrical stimulation was applied in the gastric electrical stimulation session. Gastric slow waves and emesis, as well as behaviors suggestive of nausea, were recorded during each session. The results were as follows: (1) cisplatin induced vomiting and other symptoms and induced gastric dysrhythmia. The percentage of normal slow waves decreased significantly during the 2.5 h before vomiting (P = 0.01) and the period of vomiting (P < 0.001). (2) Gastric electrical stimulation reduced emesis and the symptoms score. The total score in the control session was higher than that in the gastric electrical stimulation session (P = 0.02). However, gastric electrical stimulation had no effects on gastric dysrhythmia. It is concluded that cisplatin induces emesis and gastric dysrhythmia. Gastric electrical stimulation may play a role in relieving chemotherapy-induced emetic responses and deserves further investigation.

引用

页码：922 / 927

页数：6

共 36 条

[1] Gastric electrical stimulation for medically refractory gastroparesis [J].

Abell, T ;

McCallum, R ;

Hocking, M ;

Koch, K ;

Abrahamsson, H ;

LeBlanc, I ;

Lindberg, G ;

Konturek, J ;

Nowak, T ;

Quigley, EMM ;

Tougas, G ;

Starkebaum, W .

GASTROENTEROLOGY, 2003, 125 (02) :421-428

[2] An energy algorithm improves symptoms in some patients with gastroparesis and treated with gastric electrical stimulation [J].

Abidi, N ;

Starkebaum, WL ;

Abell, TL .

NEUROGASTROENTEROLOGY AND MOTILITY, 2006, 18 (04) :334-338

[3]

BILGUTAY A M, 1963, Biomed Sci Instrum, V1, P377

[4] TOXICOLOGY SCREENING IN SMALL ANIMALS [J].

BRADNER, WT ;

SCHURIG, JE .

CANCER TREATMENT REVIEWS, 1981, 8 (02) :93-102

[5]

CHEN J, 1992, AM J GASTROENTEROL, V87, P477

[6] SPECTRAL-ANALYSIS OF EPISODIC RHYTHMIC VARIATIONS IN THE CUTANEOUS ELECTROGASTROGRAM [J].

CHEN, JD ;

STEWART, WR ;

MCCALLUM, RW .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1993, 40 (02) :128-135

[7] Gastric electrical stimulation with short pulses reduces vomiting but not dysrhythmias in dogs [J].

Chen, JDZ ;

Qian, LW ;

Ouyang, H ;

Yin, JY .

GASTROENTEROLOGY, 2003, 124 (02) :401-409

[8]

Chen JZ., 1994, ELECTROGASTROGRAPHY

[9] EFFECT OF CISPLATIN ON MYOELECTRIC ACTIVITY OF THE STOMACH AND SMALL-INTESTINE IN DOGS [J].

CHEY, RD ;

LEE, KY ;

ASBURY, R ;

CHEY, WY .

DIGESTIVE DISEASES AND SCIENCES, 1988, 33 (03) :338-344

[10] Electrical stimulation for gastroparesis - Gastric motility restored [J].

de Csepel, J ;

Goldfarb, B ;

Shapsis, A ;

Goff, S ;

Gabriel, N ;

Eng, HM .

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2006, 20 (02) :302-306

← 1 2 3 4 →