Wilms tumor in Africa: A systematic review of management challenges and outcome in two decades (2000-2019)

被引：17

作者：

Ekenze, Sebastian O. ^{[1
]}

Okafor, Okechukwu C. ^{[2
]}

Obasi, Akputa A. ^{[3
]}

Okafor, David C. ^{[3
]}

Nnabugwu, Ikenna I. ^{[4
]}

机构：

[1] Univ Nigeria, Coll Med, Fac Med Sci, Subdept Pediat Surg, Nsukka, Enugu, Nigeria

[2] Univ Nigeria, Dept Morbid Anat, Fac Med Sci, Coll Med, Nsukka, Enugu, Nigeria

[3] Alex Ekwueme Fed Univ, Pediat Surg Unit, Teaching Hosp, Abakaliki, Nigeria

[4] Univ Nigeria, Fac Med Sci, Coll Med, Urol Unit,Dept Surg, Nsukka, Enugu, Nigeria

来源：

PEDIATRIC BLOOD & CANCER | 2020年 / 67卷 / 11期

关键词：

Africa; challenges; developing countries; meta-analysis; outcome; Wilms tumor; CHILDHOOD-CANCER; NEPHROBLASTOMA; CHILDREN; EXPERIENCE; MALAWI; PROTOCOL; REGION;

D O I：

10.1002/pbc.28695

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We performed a systematic review to highlight trends in management and outcome of Wilms tumor (WT) in Africa in the past two decades (2000-2019). Twenty-seven studies involving 2250 patients were analyzed. Overall, barring regional variations, 57.7% of the cases presented with advanced disease, 57.3% completed planned treatment, and survival was 56.5%. The publications in the two decades did not show significant differences in proportions of cases with advanced disease, completion of treatment rate, and cases lost to follow up. However, significantly more cases received preoperative chemotherapy, and survival improved in the last decade (2010-2019) compared to the earlier decade (2000-2009). Survival of WT in Africa might have improved in the last decade, but challenges of delayed presentation and abandonment of treatment have persisted. Measures that will encourage early access to expert care as well as improve on treatment compliance may further improve survival of WT in Africa.

引用

页数：9