γδ T cells in cancer

被引：460

作者：

Silva-Santos, Bruno ^{[1
]}

Serre, Karine ^{[1
]}

Norell, Hakan ^{[1
]}

机构：

[1] Univ Lisbon, Fac Med, Inst Med Mol, P-1649028 Lisbon, Portugal

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 11期

基金：

欧洲研究理事会;

关键词：

INTERFERON-GAMMA; INTRAEPITHELIAL LYMPHOCYTES; IMMUNE SURVEILLANCE; PROTECTIVE ROLE; TUMOR-IMMUNITY; RECEPTOR; RECOGNITION; DIFFERENTIATION; IMMUNOTHERAPY; CYTOTOXICITY;

D O I：

10.1038/nri3904

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

With the promise of T cell-based therapy for cancer finally becoming reality, this Review focuses on the less-studied gamma delta T cell lineage and its diverse responses to tumours gamma delta T cells have well-established protective roles in cancer, largely on the basis of their potent cytotoxicity and interferon-gamma production. Besides this, recent studies have revealed a series of tumour-promoting functions that are linked to interleukin-17-producing gamma delta T cells. Here, we integrate the current knowledge from both human and mouse studies to highlight the potential of gamma delta T cell modulation to improve cancer immunotherapy.

引用

页码：683 / 691

页数：9

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