Dimethyl Sulfoxide Participant Iron-Mediated Cascade Oxidation/α-Formylation Reaction of Substituted 2,3-Dihydropyrroles under Air and Protonic Acid Free Condition

被引：80

作者：

Zhang, Zhiguo ^{[1
]}

Tian, Qing ^{[1
]}

Qian, Jingjing ^{[1
]}

Liu, Qingfeng ^{[1
]}

Liu, Tongxin ^{[1
]}

Shi, Lei ^{[1
]}

Zhang, Guisheng ^{[1
]}

机构：

[1] Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Key Lab Green Chem Media & React, Minist Educ,Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 17期

基金：

中国博士后科学基金;

关键词：

COA REDUCTASE INHIBITORS; ACTIVATED CYCLOPROPANES; CATALYZED OXIDATION; TERTIARY-AMINES; N-METHYL; EFFICIENT; PYRROLES; INDOLES; RING; FUNCTIONALIZATION;

D O I：

10.1021/jo501385w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and Bronsted acid free one-pot protocol to directly generate structurally sophisticated alpha-formylpyrrole derivatives in moderate to good yields has been demonstrated, involving an iron-mediated domino oxidation/formylation reaction of readily available 2,3-dihydro-1H-pyrroles in dimethyl sulfoxide and air atmosphere, in which dimethyl sulfoxide acts as the formyl donor. A possible mechanism is presented.

引用

页码：8182 / 8188

页数：7

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