A Population-Based Study of Secondary Prostate Cancer Risk after Radiotherapy in Male Patients with Rectal Cancer: A Retrospective Cohort Study

被引:6
作者
Chuang, Jen-Pin [1 ,2 ]
Lee, Yen-Chien [3 ,4 ]
Lee, Jenq-Chang [5 ]
Lu, Chin-Li [6 ]
Li, Chung-Yi [7 ,8 ]
机构
[1] Natl Cheng Kung Univ, Inst Clin Med, Coll Med, Tainan 70101, Taiwan
[2] Puzi Hosp, Minist Hlth & Welf, Dept Surg, Puzi 61347, Chiayi, Taiwan
[3] Tainan Hosp, Minist Hlth & Welf, Dept Oncol, Tainan 70043, Taiwan
[4] Natl Cheng Kung Univ, Coll Med, Inst Internal Med, Tainan 70101, Taiwan
[5] Natl Cheng Kung Univ, Coll Med, Dept Surg, Tainan 70101, Taiwan
[6] Natl Chung Hsing Univ, Inst Food Safety, Coll Agr & Nat Resources, Taichung 40249, Taiwan
[7] Natl Cheng Kung Univ, Dept Publ Hlth, Coll Med, Tainan 70101, Taiwan
[8] China Med Univ, Dept Publ Hlth, Coll Publ Hlth, Taichung 40402, Taiwan
来源
MEDICINA-LITHUANIA | 2019年 / 55卷 / 04期
关键词
rectal cancer; radiotherapy; prostate cancer; RADIATION-THERAPY; CHILDHOOD-CANCER; TESTOSTERONE; NEOPLASMS; SURVIVORS; MALIGNANCIES;
D O I
10.3390/medicina55040104
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and objective: Risk of secondary prostate cancer after radiation therapy among patients with rectal cancer remains undetermined. Given an increased incidence of rectal cancer in younger people and improved survival for rectal cancer patients who received radiation therapy, the potential risk of secondary prostate cancer needs to be further investigated. Materials and Methods: Male patients (n = 11,367) newly diagnosed rectal cancer and who underwent abdominoperineal resection (APR) or low anterior resection (LAR) from 1 January, 1998 to 31 December, 2010 were identified from Taiwan National Health Insurance Research Database. The incidence and relative risk of secondary prostate cancer in study patients with (n = 1586) and without (n = 9781) radiotherapy within one year after rectal cancer diagnosis were compared using a competing-risks analysis. Results: Rectal cancer patients with radiotherapy were at a significantly decreased risk of developing prostate cancer, with a hazard ratio (HR) of 0.41 (95% confidence interval = 0.20-0.83) after adjustment for age. Analysis of the risk estimated for various follow-up lengths suggested that a decreasing HR was seen through the period followed-up and that there was a trend of decreasing prostate cancer risk with time after radiotherapy. Conclusions: Radiotherapy was significantly associated with decreased risk of secondary prostate cancer among rectal cancer patients, by a magnitude of 59%.
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页数:9
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