Enantioselective total synthesis of (2S,3R,4R)-D-xylo-phytosphingosine from substituted azetidin-2-one

被引：15

作者：

Pandey, Ganesh ^{[1
]}

Tiwari, Dharmendra Kumar ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 26期

关键词：

Enantioselective synthesis; Sphingosine; beta-Lactam; Wittig reaction; D-ERYTHRO-SPHINGOSINE; D-RIBO-PHYTOSPHINGOSINE; 4; DIASTEREOMERS; STEREOCONTROLLED SYNTHESIS; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; THREO-SPHINGOSINE; FORMAL SYNTHESIS; BETA-LACTAMS; SPHINGOLIPIDS;

D O I：

10.1016/j.tetlet.2009.02.050

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiomerically pure (2S,3R,4R)-D-xylo phytosphingosine is synthesized in 36% overall yield in seven steps from known beta-lactam (8) derived from D-mannitol triacetonide. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3296 / 3298

页数：3

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