Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses

被引：19

作者：

Brown, Jennifer R. ^{[1
,2
,3
]}

Walker, Sarah R. ^{[1
,2
,3
]}

Heppler, Lisa N. ^{[1
]}

Tyekucheva, Svitlana ^{[4
]}

Nelson, Erik A. ^{[1
,2
,3
]}

Klitgaard, Josephine ^{[1
]}

Nicolais, Maria ^{[1
]}

Kroll, Yasmin ^{[1
]}

Xiang, Michael ^{[1
]}

Yeh, Jennifer E. ^{[1
]}

Chaudhury, Mousumi ^{[1
]}

Giaccone, Zachary T. ^{[1
]}

Fernandes, Stacey M. ^{[1
]}

Jacobsen, Eric D. ^{[1
,2
,3
]}

Fisher, David C. ^{[1
,2
,3
]}

Freedman, Arnold S. ^{[1
,2
,3
]}

Davids, Matthew S. ^{[1
,2
,3
]}

Supko, Jeffrey G. ^{[5
]}

Wu, Catherine ^{[1
,2
,3
]}

Frank, David A. ^{[1
,2
,3
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, 450 Brookline Ave,Mayer 522B, Boston, MA 02215 USA

[2] Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA

[3] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

[4] Dana Farber Canc Inst, Dept Data Sci, Boston, MA 02115 USA

[5] Harvard Med Sch, Dept Med, Massachusetts Gen Hosp, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2021年 / 96卷 / 04期

关键词：

TRANSCRIPTION;

D O I：

10.1002/ajh.26084

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E95 / E98

页数：4

共 50 条

[41] A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation
Zhang, Xiaolei
Sun, Ying
Pireddu, Roberta
Yang, Hua
Urlam, Murali K.
Lawrence, Harshani R.
Guida, Wayne C.
Lawrence, Nicholas J.
Sebti, Said M.
CANCER RESEARCH, 2013, 73 (06) : 1922 - 1933
[42] B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT)1 and STAT3 constitutively phosphorylated on serine residues
Frank, DA
Mahajan, S
Ritz, J
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (12): : 3140 - 3148
[43] Stat3 as a Therapeutic Target for the Treatment of Psoriasis: A Clinical Feasibility Study with STA-21, a Stat3 Inhibitor
Miyoshi, Ken
Takaishi, Mikiro
Nakajima, Kimiko
Ikeda, Mitsunori
Kanda, Takashi
Tarutani, Masahito
Iiyama, Tatsuo
Asao, Naoki
DiGiovanni, John
Sano, Shigetoshi
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (01) : 108 - 117
[44] STAT3 mutations are highly specific for large granular lymphocytic leukemia
Fasan, A.
Kern, W.
Grossmann, V.
Haferlach, C.
Haferlach, T.
Schnittger, S.
LEUKEMIA, 2013, 27 (07) : 1598 - 1600
[45] SOMATIC MUTATIONS IN STAT3 DRIVE LARGE GRANULAR LYMPHOCYTIC LEUKEMIA
不详
CANCER DISCOVERY, 2012, 2 (07) : 579 - 579
[46] STAT3 mutations are highly specific for large granular lymphocytic leukemia
A Fasan
W Kern
V Grossmann
C Haferlach
T Haferlach
S Schnittger
Leukemia, 2013, 27 : 1598 - 1600
[47] STAT3 is constitutively activated in Hodgkin cell lines
Kube, D
Holtick, U
Vockerodt, M
Ahmadi, T
Haier, B
Behrmann, I
Heinrich, PC
Diehl, V
Tesch, H
BLOOD, 2001, 98 (03) : 762 - 770
[48] Constitutively activated STAT3 in myeloma cells.
Grigorieva, I
Chapman, M
Epstein, J
BLOOD, 1996, 88 (10) : 404 - 404
[49] STAT3 promotes chronic lymphocytic leukemia progression through upregulating SMYD3 expression
Ma, Wei
Zhang, Yingying
Qi, Yu
Guo, Shidong
ARCHIVES OF MEDICAL SCIENCE, 2019, 15 (05) : 1163 - 1175
[50] Targeting Stat3 in tumors & chronic inflammation: rS3-PA, a peptide-based inhibitor, efficiently blocks Stat3 function in vitro and in vivo
Mack, L. M.
Borghouts-Heinz, C.
Brill, B.
Delis, N.
Groner, B.
JOURNAL OF PEPTIDE SCIENCE, 2010, 16 : 128 - 129

← 1 2 3 4 5 →