Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses

被引:19
|
作者
Brown, Jennifer R. [1 ,2 ,3 ]
Walker, Sarah R. [1 ,2 ,3 ]
Heppler, Lisa N. [1 ]
Tyekucheva, Svitlana [4 ]
Nelson, Erik A. [1 ,2 ,3 ]
Klitgaard, Josephine [1 ]
Nicolais, Maria [1 ]
Kroll, Yasmin [1 ]
Xiang, Michael [1 ]
Yeh, Jennifer E. [1 ]
Chaudhury, Mousumi [1 ]
Giaccone, Zachary T. [1 ]
Fernandes, Stacey M. [1 ]
Jacobsen, Eric D. [1 ,2 ,3 ]
Fisher, David C. [1 ,2 ,3 ]
Freedman, Arnold S. [1 ,2 ,3 ]
Davids, Matthew S. [1 ,2 ,3 ]
Supko, Jeffrey G. [5 ]
Wu, Catherine [1 ,2 ,3 ]
Frank, David A. [1 ,2 ,3 ]
机构
[1] Dana Farber Canc Inst, Dept Med Oncol, 450 Brookline Ave,Mayer 522B, Boston, MA 02215 USA
[2] Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA
[3] Harvard Med Sch, Dept Med, Boston, MA 02115 USA
[4] Dana Farber Canc Inst, Dept Data Sci, Boston, MA 02115 USA
[5] Harvard Med Sch, Dept Med, Massachusetts Gen Hosp, Boston, MA 02115 USA
关键词
TRANSCRIPTION;
D O I
10.1002/ajh.26084
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E95 / E98
页数:4
相关论文
共 50 条
  • [1] A Clinical Trial of the STAT3 Inhibitor Pyrimethamine in Chronic Lymphocytic Leukemia
    Brown, Jennifer R.
    Walker, Sarah R.
    Heppler, Lisa N.
    Tyekucheva, Svitlana
    Nelson, Erik
    Klitgaard, Josephine L.
    Nicolais, Maria
    Kroll, Yasmin
    Xiang, Michael
    Yeh, Jennifer E.
    Chaudhury, Mousumi
    Giaccone, Zachary T.
    Fernandes, Stacey
    Supko, Jeffrey G.
    Wu, Catherine J.
    Frank, David A.
    BLOOD, 2018, 132
  • [2] Targeting the STAT3 pathway with STAT3 degraders
    Wang, Zhijie
    Liao, Xiaotong
    He, Haiqi
    Guo, Xia
    Chen, Jianjun
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2024, 45 (09) : 811 - 823
  • [3] At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells
    Rozovski, Uri
    Harris, David M.
    Li, Ping
    Liu, Zhiming
    Wu, Ji Yuan
    Grgurevic, Srdana
    Faderl, Stefan
    Ferrajoli, Alessandra
    Wierda, William G.
    Martinez, Matthew
    Verstovsek, Srdan
    Keating, Michael J.
    Estrov, Zeev
    JOURNAL OF IMMUNOLOGY, 2016, 196 (10): : 4400 - 4409
  • [4] Novel STAT3 inhibitors targeting the STAT3 dimerization
    Hua, Yaping
    Azeem, Waqas
    Oyan, Anne Margrete
    Kalland, Karl-Henning
    CANCER RESEARCH, 2022, 82 (12)
  • [5] Generation and characterization of a constitutively active Stat3 protein
    Barboza, JA
    Wang, SG
    Schaefer, TS
    MOLECULAR BIOLOGY REPORTS, 2004, 31 (01) : 13 - 21
  • [6] Generation and characterization of a constitutively active Stat3 protein
    Juan A. Barboza
    Shuguang Wang
    Timothy S. Schaefer
    Molecular Biology Reports, 2004, 31 : 13 - 21
  • [7] Lymphocytes from patients with chronic lymphocytic leukemia contain STAT1 and STAT3 constitutively phosphorylated on serine.
    Mahajan, S
    Rudders, SA
    Ritz, J
    Frank, DA
    BLOOD, 1996, 88 (10) : 1171 - 1171
  • [8] Constitutively Activated STAT3 Induces the Expression of Gli1 in Chronic Lymphocytic Leukemia Cells
    Rozovski, Uri
    Harris, David M.
    Li, Ping
    Liu, Zhiming
    Manshouri, Taghi
    Veletic, Ivo
    Jain, Preetesh
    Ferrajoli, Alessandra
    Burger, Jan A.
    Bose, Prithviraj
    Thompson, Philip A.
    Jain, Nitin
    Verstovsek, Srdan
    Wierda, William G.
    Keating, Michael J.
    Estrov, Zeev E.
    BLOOD, 2019, 134
  • [9] Acute myeloid leukemia cells contain constitutively activated STAT3 and require STAT3 for survival.
    Kim, TK
    Carroll, M
    Gewirtz, AM
    BLOOD, 2004, 104 (11) : 919A - 920A
  • [10] STAT3 Activates the Pentraxin 3 Gene in Chronic Lymphocytic Leukemia Cells
    Rozovski, Uri
    Veletic, Ivo
    Harris, David M.
    Li, Ping
    Liu, Zhiming
    Jain, Preetesh
    Manshouri, Taghi
    Ferrajoli, Alessandra
    Burger, Jan A.
    Bose, Prithviraj
    Thompson, Phillip A.
    Jain, Nitin
    Wierda, William G.
    Verstovsek, Srdan
    Keating, Michael J.
    Estrov, Zeev
    JOURNAL OF IMMUNOLOGY, 2022, 208 (12): : 2847 - 2855