Recombination-mediated escape from primary CD8+T cells in acute HIV-1 infection

被引：24

作者：

Ritchie, Adam John ^{[1
]}

Cai, Fangping ^{[2
]}

Smith, Nicola M. G. ^{[3
]}

Chen, Sheri ^{[2
]}

Song, Hongshuo ^{[2
]}

Brackenridge, Simon ^{[3
]}

Karim, Salim S. Abdool ^{[4
]}

Korber, Bette T. ^{[5
,6
]}

McMichael, Andrew J. ^{[3
]}

Gao, Feng ^{[2
,7
]}

Goonetilleke, Nilu ^{[8
]}

机构：

[1] Univ Oxford, Blavatnik Sch Govt, Oxford OX1 4JJ, England

[2] Duke Univ, Dept Med, Durham, NC 27710 USA

[3] Univ Oxford, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[4] Univ KwaZulu Natal, ZA-4041 Durban, South Africa

[5] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA

[6] Santa Fe Inst, Santa Fe, NM 87501 USA

[7] Jilin Univ, Coll Life Sci, Natl Engn Lab AIDS Vaccine, Changchun 130023, Jilin, Peoples R China

[8] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

RETROVIROLOGY | 2014年 / 11卷

关键词：

HIV-1; T cell; Multiple infection; Recombination; Immunodominance; Acute infection; HUMAN-IMMUNODEFICIENCY-VIRUS; DUAL INFECTION; DISEASE PROGRESSION; VARIANTS; VIREMIA; HLA; TRANSMISSION; REPLICATION; ASSOCIATION; RESPONSES;

D O I：

10.1186/s12977-014-0069-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. Results: Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef. Conclusions: Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.

引用

页码：1 / 10

页数：10

共 45 条

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