CT imaging features of antiresorptive agent-related osteonecrosis of the jaw/medication-related osteonecrosis of the jaw

被引:40
作者
Baba, Akira [1 ]
Goto, Tazuko K. [2 ]
Ojiri, Hiroya [3 ]
Takagiwa, Mutsumi [4 ]
Hiraga, Chiho [5 ]
Okamura, Masahiro [5 ]
Hasegawa, Sho [5 ]
Okuyama, Yumi [1 ]
Ogino, Nobuhiro [2 ]
Yamauchi, Hideomi [2 ]
Kobashi, Yuko [1 ]
Yamazoe, Shinji [1 ]
Munetomo, Yohei [1 ]
Mogami, Takuji [1 ]
Nomura, Takeshi [5 ]
机构
[1] Ichikawa Gen Hosp, Tokyo Dent Coll, Dept Radiol, Ichikawa, Chiba, Japan
[2] Tokyo Dent Coll, Dept Oral & Maxillofacial Radiol, Tokyo, Japan
[3] Jikei Univ, Sch Med, Dept Radiol, Tokyo, Japan
[4] Tokyo Dent Coll, Lab Math, Tokyo, Japan
[5] Ichikawa Gen Hosp, Tokyo Dent Coll, Dept Oral & Maxillofacial Surg, Ichikawa, Chiba, Japan
关键词
bisphophonate; Denosumab; Computed tomography; medication-relatedosteone-crosis of the jaw; BISPHOSPHONATE-ASSOCIATED OSTEONECROSIS; BEAM COMPUTED-TOMOGRAPHY; MEDICATION-RELATED OSTEONECROSIS; PANORAMIC RADIOGRAPHY; POSTMENOPAUSAL OSTEOPOROSIS; ZOLEDRONIC ACID; POSITION PAPER; BONE; DENOSUMAB; CANCER;
D O I
10.1259/dmfr.20170323
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objectives: Antiresorptive agent-related osteonecrosis of the jaw (ARONJ)/medicationrelated osteonecrosis of the jaw (MRONJ) include both bisphosphonate-related osteonecrosis of jaw (BRONJ) and denosumab-related osteonecrosis of jaw (DRONJ). The purpose of this study is to study radiological characteristics of ARONJ/MRONJ. These imaging features may serve as one useful aid for assessing ARONJ/MRONJ. Methods: CT scans of 74 Japanese patients, who were clinically diagnosed by inclusion criteria of ARONJ/MRONJ, obtained between April 1, 2011 and September 30, 2016, were evaluated. We investigated the CT imaging features of ARONJ/MRONJ, and clarified radiological differentiation between BRONJ and DRONJ, BRONJ due to oral bisphosphonate administration and due to intravenous bisphosphonate administration, BRONJ with respective kinds of medication, BRONJ with long-term administration and short-term administration, BRONJ with each clinical staging respectively. Fisher's exact test, chi(2) test, Student's t-test and analysis of variance were performed in the statistical analyses. Results: Unilateral maxillary sinusitis was detected in all patients with upper ARONJ/MRONJ (100%). DRONJ showed large sequestrum more frequently than BRONJ (3/4, 75 vs 3/35, 8.6%, p < 0.05). DRONJ showed periosteal reaction more frequently than BRONJ (4/10, 40 vs 7/65, 10.1%, p < 0.05). Patients of BRONJ resulting from intravenous bisphosphonate administration showed larger and more frequent buccolingual cortical bone perforations than BRONJ resulting from oral bisphosphonate administration (7/8, 87.5 vs 11/30, 36.7%, p < 0.05). There was no significant correlation between CT findings and respective kinds of medication, long/short-term administration, clinical stages of BRONJ. Conclusions: ARONJ/MRONJ has characteristic CT image findings which could be useful for its assessment.
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页数:10
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