Air-pulse OCE for assessment of age-related changes in mouse cornea in vivo

被引：65

作者：

Li, Jiasong ^{[1
]}

Wang, Shang ^{[1
]}

Singh, M. ^{[1
]}

Aglyamov, S. ^{[2
]}

Emelianov, S. ^{[2
]}

Twa, M. D. ^{[3
]}

Larin, K. V. ^{[1
,4
]}

机构：

[1] Univ Houston, Dept Biomed Engn, Houston, TX 77004 USA

[2] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA

[3] Univ Houston, Coll Optometry, Houston, TX 77204 USA

[4] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA

来源：

LASER PHYSICS LETTERS | 2014年 / 11卷 / 06期

关键词：

optical coherence tomography; cornea; in vivo; mechanic property; relaxation rate; OPTICAL COHERENCE TOMOGRAPHY; BIOMECHANICAL PROPERTIES; ELASTICITY; TISSUE; ELASTOGRAPHY; STRAIN; QUANTIFICATION; DEFORMATION; MICROSCOPY; WAVES;

D O I：

10.1088/1612-2011/11/6/065601

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate the use of phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to assess the relaxation rate of deformation created by a focused air-pulse in tissue-mimicking gelatin phantoms of various concentrations and mouse corneas of different ages in vivo. The results show that the relaxation rate can be quantified and is different for gels with varying concentrations of gelatin and mouse corneas of different ages. The results indicate that gel phantoms with higher concentrations of gelatin as well as older mouse corneas have faster relaxation rates indicating stiffer material. This non-contact and non-invasive measurement technique utilizes low surface displacement amplitude (in mu m scale) for tissue excitation and, therefore, can be potentially used to study the biomechanical properties of ocular and other sensitive tissues.

引用

页数：4