Insulin and free oestradiol are independent risk factors for benign prostatic hyperplasia

被引：68

作者：

Hammarsten, J. ^{[1
]}

Damber, J-E ^{[2
]}

Karlsson, M. ^{[3
,4
]}

Knutson, T. ^{[2
]}

Ljunggren, O. ^{[5
]}

Ohlsson, C. ^{[6
]}

Peeker, R. ^{[2
]}

Smith, U. ^{[7
]}

Mellstrom, D. ^{[6
,8
]}

机构：

[1] Skaraborg Hosp, Dept Urol, S-43237 Verberg, Sweden

[2] Sahlgrens Univ Hosp, Inst Clin Sci, Dept Urol, Gothenburg, Sweden

[3] Lund Univ, Malmo Gen Hosp, Dept Clin Sci, S-21401 Malmo, Sweden

[4] Lund Univ, Malmo Gen Hosp, Dept Orthoped, S-21401 Malmo, Sweden

[5] Univ Uppsala Hosp, Dept Med Sci, Uppsala, Sweden

[6] Sahlgrens Univ Hosp, Ctr Bone Res, Sahlgrenska Acad, Dept Internal Med, Gothenburg, Sweden

[7] Univ Gothenburg, Dept Internal Med, Sahlgrenska Acad, Lundberg Lab Diabet Res, Gothenburg, Sweden

[8] Sahlgrens Univ Hosp, Ctr Bone Res, Sahlgrenska Acad, Dept Geriatr, Gothenburg, Sweden

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2009年 / 12卷 / 02期

基金：

瑞典研究理事会;

关键词：

benign prostatic hyperplasia; insulin; lean body mass; oestradiol; the metabolic syndrome; GROWTH-FACTOR-I; METABOLIC SYNDROME; BODY-COMPOSITION; SEX-HORMONES; DOUBLE-BLIND; TESTOSTERONE; OBESITY; VOLUME; AROMATASE; HYPERINSULINEMIA;

D O I：

10.1038/pcan.2008.50

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aetiology of benign prostatic hyperplasia (BPH) remains unclear. The objective of the present study was to test the insulin, oestradiol and metabolic syndrome hypotheses as promoters of BPH. The design was a risk factor analysis of BPH in which the total prostate gland volume was related to endocrine and anthropometric factors. The participants studied were 184 representative men, aged 72-76 years, residing in Goteborg, Sweden. Using a multivariate analysis, BPH as measured by the total prostate gland volume correlated statistically significantly with fasting serum insulin (beta = 0.200, P = 0.028), free oestradiol (beta = 0.233, P = 0.008) and lean body mass (beta = 0.257, P = 0.034). Insulin and free oestradiol appear to be independent risk factors for BPH, confirming both the insulin and the oestradiol hypotheses. Our findings also seem to confirm the metabolic syndrome hypothesis. The metabolic syndrome and its major endocrine aberration, hyperinsulinaemia, are possible primary events in BPH. Prostate Cancer and Prostatic Diseases (2009) 12, 160-165; doi:10.1038/pcan.2008.50; published online 30 September 2008

引用

页码：160 / 165

页数：6

共 42 条

[1] What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? [J].