Chitosan/lecithin liposomal nanovesicles as an oral insulin delivery system

被引：50

作者：

Al-Remawi, Mayyas ^{[1
]}

Elsayed, Amani ^{[2
]}

Maghrabi, Ibrahim ^{[3
]}

Hamaidi, Mohammad ^{[2
]}

Jaber, Nisrein ^{[4
]}

机构：

[1] Petra Univ, Fac Pharm & Med Sci, Dept Pharmaceut & Pharmaceut Technol, Amman, Jordan

[2] Taif Univ, Coll Pharm, Dept Pharmaceut & Pharmaceut Technol, POB 888, At Taif 21944, Saudi Arabia

[3] Taif Univ, Coll Pharm, Dept Clin Pharm, At Taif, Saudi Arabia

[4] Jordan Food & Drug Adm, Dept Drug Registrat, Amman, Jordan

来源：

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2017年 / 22卷 / 03期

关键词：

Chitosan; insulin; lecithin; nanovesicles; liposomes; MOLECULAR-WEIGHT CHITOSAN; COATED LIPOSOMES; DRUG-DELIVERY; DIABETIC-RATS; NANOPARTICLES; PH; STABILIZATION; ENCAPSULATION; STABILITY; PROTEINS;

D O I：

10.1080/10837450.2016.1213745

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present work, insulin-chitosan polyelectrolyte complexes associated to lecithin liposomes were investigated as a new carrier for oral delivery of insulin. The preparation was characterized in terms of particle size, zeta potential and encapsulation efficiency. Surface tension measurements revealed that insulin-chitosan polyelectrolyte complexes have some degree of hydrophobicity and should be added to lecithin liposomal dispersion and not the vice versa to prevent their adsorption on the surface. Stability of insulin was enhanced when it was associated to liposomes. Significant reduction of blood glucose levels was noticed after oral administration of liposomal preparation to streptozotocin diabetic rats compared to control. The hypoglycemic activity was more prolonged compared to subcutaneously administered insulin.

引用

页码：390 / 398

页数：9

共 43 条

[1] Low Molecular Weight Chitosan-Insulin Polyelectrolyte Complex: Characterization and Stability Studies [J].

Al-Kurdi, Zakieh I. ;

Chowdhry, Babur Z. ;

Leharne, Stephen A. ;

Al Omari, Mahmoud M. H. ;

Badwan, Adnan A. .

MARINE DRUGS, 2015, 13 (04) :1765-1784

[2] Oral delivery of insulin using a lipoamino acid nanocarrier system [J].

Al-Remawi, M. ;

Maghrabi, I. ;

Elsayed, A. ;

Hamaidi, M. ;

Jaber, N. .

PHARMAZIE, 2014, 69 (09) :669-675

[3]

Al-Sou'od K, 2013, JORDAN J CHEM, V8, P1

[4]

Arbit E., 2014, DIABETES TECHNOL THE, V6, P510

[5] Encapsulation of calcitonin in liposomes depends on the vesicle preparation method [J].

Arien, A ;

Dupuy, B .

JOURNAL OF MICROENCAPSULATION, 1997, 14 (06) :753-760

[6]

Badwan A, 2007, International patent, Patent No. 2007068311

[7] Role of arginine in the stabilization of proteins against aggregation [J].

Baynes, BM ;

Wang, DIC ;

Trout, BL .

BIOCHEMISTRY, 2005, 44 (12) :4919-4925

[8] In situ quantitative visualization and characterization of chitosan electrodeposition with paired sidewall electrodes [J].

Cheng, Yi ;

Luo, Xiaolong ;

Betz, Jordan ;

Buckhout-White, Susan ;

Bekdash, Omar ;

Payne, Gregory F. ;

Bentley, William E. ;

Rubloff, Gary W. .

SOFT MATTER, 2010, 6 (14) :3177-3183

[9] GASTROINTESTINAL UPTAKE OF LIPOSOMES .1. INVITRO AND INSITU STUDIES [J].

CHIANG, CM ;

WEINER, N .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 37 (1-2) :75-85

[10] Control of pH during plasmid preparation by alkaline lysis of Escherichia coli [J].

Cloninger, Cheri ;

Felton, Marilyn ;

Paul, Bonnie ;

Hirakawa, Yasuko ;

Metzenberg, Stan .

ANALYTICAL BIOCHEMISTRY, 2008, 378 (02) :224-225

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