Gender-dependent impacts of body mass index and moderate alcohol consumption on serum uric acid-an index of oxidant stress status?

被引:22
作者
Alatalo, Paivikki I. [1 ,2 ,3 ]
Koivisto, Heidi M. [1 ,2 ,3 ]
Hietala, Johanna P. [1 ,2 ,3 ]
Bloigu, Risto S. [4 ]
Niemela, Onni J. [1 ,2 ,3 ]
机构
[1] Seinajoki Cent Hosp, Dept Lab Med, FIN-60220 Seinajoki, Finland
[2] Seinajoki Cent Hosp, Med Res Unit, FIN-60220 Seinajoki, Finland
[3] Univ Tampere, FIN-60220 Seinajoki, Finland
[4] Univ Oulu, Med Informat Grp, Oulu, Finland
关键词
Ethanol; Obesity; Urate; Oxidative stress; Estrogen; Free radicals; GAMMA-GLUTAMYL-TRANSFERASE; OXIDATIVE STRESS; ALANINE AMINOTRANSFERASE; ANTIOXIDANT CAPACITY; METABOLIC SYNDROME; LIVER-DISEASE; RED WINE; RISK; SEX; HYPERTENSION;
D O I
10.1016/j.freeradbiomed.2009.02.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Uric acid seems to be causally involved in a variety of medical disorders involving oxidative stress. Although alcohol abuse and obesity are known to increase serum uric acid, the interactions between moderate drinking, adiposity, and uric acid metabolism have remained poorly understood. We examined serum uric acid concentrations from 2062 apparently healthy volunteers (970 men, 1092 women) reporting either no alcohol (abstainers) or <40 g of ethanol consumption per day (moderate drinkers). The study population was further classified according to BMI as follows: <19 (underweight), 19-25 (normal weight), 25-30 (overweight), and >30 (obese). Serum uric acid concentrations in male moderate drinkers were significantly higher, and in females they were lower, than in the corresponding groups of abstainers. In the BMI-based subgroups, the highest concentrations were found in those who were overweight or obese. Significant two-factor interactions occurred between gender and drinking status (p<0.001) and between gender and BMI (p<0.02). Serum uric acid also correlated with indices of hepatocellular health (GGT, ALT, AST). The data indicate distinct gender-dependent impacts of alcohol consumption and BMI on serum uric acid. These findings should be applicable to the assessment of oxidative stress status and associated morbidity in alcohol consumers and individuals with excess body weight. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:1233 / 1238
页数:6
相关论文
共 63 条
[1]   Effect of moderate alcohol consumption on liver enzymes increases with increasing body mass index [J].
Alatalo, Paeivikki I. ;
Koivisto, Heidi M. ;
Hietala, Johanna P. ;
Puukka, Katri S. ;
Bloigu, Risto ;
Niemelae, Onni J. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2008, 88 (04) :1097-1103
[2]   Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids [J].
Almeida, Maria ;
Han, Li ;
Martin-Millan, Marta ;
Plotkin, Lilian I. ;
Stewart, Scott A. ;
Roberson, Paula K. ;
Kousteni, Stavroula ;
O'Brien, Charles A. ;
Bellido, Teresita ;
Parfitt, A. Michael ;
Weinstein, Robert S. ;
Jilka, Robert L. ;
Manolagas, Stavros C. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (37) :27285-27297
[3]   URIC-ACID PROVIDES AN ANTIOXIDANT DEFENSE IN HUMANS AGAINST OXIDANT-CAUSED AND RADICAL-CAUSED AGING AND CANCER - A HYPOTHESIS [J].
AMES, BN ;
CATHCART, R ;
SCHWIERS, E ;
HOCHSTEIN, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :6858-6862
[4]   TOWARDS THE PHYSIOLOGICAL-FUNCTION OF URIC-ACID [J].
BECKER, BF .
FREE RADICAL BIOLOGY AND MEDICINE, 1993, 14 (06) :615-631
[5]   Molecular mediators of hepatic steatosis and liver injury [J].
Browning, JD ;
Horton, JD .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (02) :147-152
[6]   Oxidative stress, toxicology, and pharmacology of CYP2E1 [J].
Caro, AA ;
Cederbaum, AI .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2004, 44 :27-42
[7]   Higher concentrations of alanine aminotransferase within the reference interval predict nonalcoholic fatty liver disease [J].
Chang, Yoosoo ;
Ryu, Seungho ;
Sung, Eunju ;
Jang, Yumi .
CLINICAL CHEMISTRY, 2007, 53 (04) :686-692
[8]   Plasma uric acid and the risk of type 2 diabetes in a Chinese community [J].
Chien, Kuo-Liong ;
Chen, Ming-Fong ;
Hsu, Hsiu-Ching ;
Chang, Wei-Tien ;
Su, Ta-Chen ;
Lee, Yuan-Teh ;
Hu, Frank B. .
CLINICAL CHEMISTRY, 2008, 54 (02) :310-316
[9]  
Conway B, 2004, Obes Rev, V5, P145, DOI 10.1111/j.1467-789X.2004.00144.x
[10]   URIC-ACID IRON-ION COMPLEXES - A NEW ASPECT OF THE ANTIOXIDANT FUNCTIONS OF URIC-ACID [J].
DAVIES, KJA ;
SEVANIAN, A ;
MUAKKASSAHKELLY, SF ;
HOCHSTEIN, P .
BIOCHEMICAL JOURNAL, 1986, 235 (03) :747-754