Conjugated linoleic acid reduces parathyroid hormone in health and in polycystic kidney disease in rats

被引：0
作者：
Weiler, H
Austin, S
Wong, SF
Nitschmann, E
Bankovic-Calic, N
Mollard, R
Aukema, H
Ogborn, M
机构：
[1] Univ Manitoba, Dept Human Nutr Sci, Winnipeg, MB R3T 2N2, Canada
[2] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB R3T 2N2, Canada
来源：
AMERICAN JOURNAL OF CLINICAL NUTRITION | 2004年 / 79卷 / 06期
关键词：
polycystic kidney disease; bone metabolism; parathyroid hormone; conjugated linoleic acid; Han : SPRD-cy rats;
D O I：
暂无
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Background: Feeding conjugated linoleic acid (CLA) is reported to reduce prostaglandin E-2 synthesis, which is required for parathyroid hormone (PTH) release. Objective: This study was undertaken to determine whether CLA would suppress hyperparathyroidism and the resulting high-turnover bone disease in a rat model of polycystic kidney disease (PKD). Design: Outcome measurements were conducted after 8 wk of feeding diets supplemented with and without CLA (1% of dietary fat) to Han:SPRD-cy male rats (n = 52). PTH, bone formation, and resorption were assessed in addition to femur bone mass with use of dual-energy X-ray absorptiometry. Results: CLA feeding resulted in attenuation of PTH concentrations in both PKD-affected and nonaffected rats (by 60%) but did not significantly alter bone formation and resorption. Conclusion: Reduction in PTH may open possibilities for CLA as an adjunctive therapy in secondary hyperparathyroidism.
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收藏
页码：1186S / 1189S
页数：4
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