How free fatty acids inhibit glucose utilization in human skeletal muscle

被引：136

作者：

Roden, M ^{[1
]}

机构：

[1] Hanusch Hosp, Dept Med 1, A-1140 Vienna, Austria

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2004年 / 19卷

关键词：

D O I：

10.1152/nips.01459.2003

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Rat muscle studies suggest competition between free fatty acids (FFA) and glucose for oxidation, resulting in glucose-6-phosphate accumulation. However, FFA decrease glucose-6-phosphate in human skeletal muscle, indicating direct inhibition of glucose transport/phosphorylation. This mechanism could redirect glucose from muscle to brain during fasting and explain the insulin resistance associated with high-lipid diets and obesity.

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收藏

页码：92 / 96

页数：5

相关论文

共 26 条

[1] AN ABNORMALITY OF NONESTERIFIED FATTY ACID METABOLISM IN DIABETES MELLITUS [J].

BIERMAN, EL ;

DOLE, VP ;

ROBERTS, TN .

DIABETES, 1957, 6 (06) :475-479

[2] MECHANISMS OF FATTY ACID-INDUCED INHIBITION OF GLUCOSE-UPTAKE [J].

BODEN, G ;

CHEN, XH ;

RUIZ, J ;

WHITE, JV ;

ROSSETTI, L .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (06) :2438-2446

[3] EFFECTS OF FAT ON INSULIN-STIMULATED CARBOHYDRATE-METABOLISM IN NORMAL MEN [J].

BODEN, G ;

JADALI, F ;

WHITE, J ;

LIANG, Y ;

MOZZOLI, M ;

CHEN, X ;

COLEMAN, E ;

SMITH, C .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (03) :960-966

[4] Skeletal muscle phosphatidylcholine fatty acids and insulin sensitivity in normal humans [J].

Clore, JN ;

Li, J ;

Gill, R ;

Gupta, S ;

Spencer, R ;

Azzam, A ;

Zuelzer, W ;

Rizzo, WB ;

Blackard, WG .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1998, 275 (04) :E665-E670

[5] Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity [J].

Dresner, A ;

Laurent, D ;

Marcucci, M ;

Griffin, ME ;

Dufour, S ;

Cline, GW ;

Slezak, LA ;

Andersen, DK ;

Hundal, RS ;

Rothman, DL ;

Petersen, KF ;

Shulman, GI .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (02) :253-259

[6] Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α [J].

Itani, SI ;

Ruderman, NB ;

Schmieder, F ;

Boden, G .

DIABETES, 2002, 51 (07) :2005-2011

[7] EFFECT OF INCREASED FREE FATTY-ACID SUPPLY ON GLUCOSE-METABOLISM AND SKELETAL-MUSCLE GLYCOGEN-SYNTHASE ACTIVITY IN NORMAL MAN [J].

JOHNSON, AB ;

ARGYRAKI, M ;

THOW, JC ;

COOPER, BG ;

FULCHER, G ;

TAYLOR, R .

CLINICAL SCIENCE, 1992, 82 (02) :219-226

[8] Fuel selection in human skeletal muscle in insulin resistance - A reexamination [J].

Kelley, DE ;

Mandarino, LJ .

DIABETES, 2000, 49 (05) :677-683

[9] Free fatty acids inhibit the glucose-stimulated increase of intramuscular glucose-6-phosphate concentration in humans [J].

Krebs, M ;

Krssak, M ;

Nowotny, P ;

Weghuber, D ;

Gruber, S ;

Mlynarik, V ;

Bischof, M ;

Stingl, H ;

Fürnsinn, C ;

Waldhäusl, W ;

Roden, M .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (05) :2153-2160

[10] Fatty acid-induced insulin resistance: Decreased muscle PI3K activation but unchanged Akt phosphorylation [J].

Kruszynska, YT ;

Worrall, DS ;

Ofrecio, J ;

Frias, JP ;

Macaraeg, G ;

Olefsky, JM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (01) :226-234