Novel Peptide Mimetic Inhibitors of Hepatitis C Serine Protease Derived from Isomannide

被引：17
作者：
Barros, Thalita G. [1 ,2 ]
Pinheiro, Sergio [2 ]
Williamson, John S. [3 ]
Tanuri, Amilcar [4 ]
Pereira, Helena S. [3 ,4 ,5 ]
Brindeiro, Rodrigo M. [4 ]
Neto, Jose B. A. [4 ]
Antunes, Octavio A. C. [6 ]
Muri, Estela M. F. [1 ]
机构：
[1] Univ Fed Fluminense, Fac Farm, BR-24241000 Niteroi, RJ, Brazil
[2] Univ Fed Fluminense, Inst Quim, BR-24020150 Niteroi, RJ, Brazil
[3] Univ Mississippi, Sch Pharm, Dept Med Chem, University, MS 38677 USA
[4] Univ Fed Rio de Janeiro, ICB, Mol Virol Lab, BR-21941570 Rio de Janeiro, Brazil
[5] Univ Fed Fluminense, Fac Odontol Nova Friburgo, BR-28625650 Nova Friburgo, RJ, Brazil
[6] Univ Fed Rio de Janeiro, Lab Catalise, Inst Quim, BR-21941909 Rio de Janeiro, Brazil
来源：
SYNTHESIS-STUTTGART | 2009年 / 04期
关键词：
peptides; antiviral agent; fused-ring systems; isomannide; hepatitis C; IONIC LIQUIDS; POTENTIAL INHIBITORS; ACID; FLAVIVIRUSES; RESISTANT; CATALYSTS; EFFICIENT;
D O I：
10.1055/s-0028-1083332
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Hepatitis C (HCV) infection is a cause of chronic liver disease such as cirrhosis, carcinoma, or liver failure, and the current therapy is effective in only 50% of patients. Serine proteases, which are present in HCV, are the Most Studied class of proteolytic enzymes, and are a primary target in the drug development field. In this paper, we describe the synthesis and biological studies of a novel class of peptide mimetic compounds as potential HCV serine protease inhibitors.
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页码：620 / 626
页数：7
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