Synthesis of Podophyllotoxin and its Derivatives via NiCl2/NaBH4 Reduction of Isoxazoline Ring

被引：4

作者：

Babu, Meduri Suresh ^{[1
]}

Rai, Kuria Madhavu Lokanatha ^{[1
]}

机构：

[1] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 17期

关键词：

Nickel chloride; Isoxazoline; Podophyllotoxin; Manganese acetate; DIELS-ALDER REACTION; GAMMA-LACTONES; 1,3-DIPOLAR CYCLOADDITIONS; NITRILE OXIDES; LIGNANS; ROUTE; ANNULATION; OXIDATION; ACETATE; SERIES;

D O I：

10.14233/ajchem.2013.15073

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel synthesis of podophyllotoxin was carried out in four steps. The key step was reduction of isoxazoline ring followed by diazotization and the resultant alkene was treated with Mn(OAc)(3)/CH3COOK to form podophyllotoxin.

引用

页码：9555 / 9557

页数：3

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