Synthesis of Podophyllotoxin and its Derivatives via NiCl2/NaBH4 Reduction of Isoxazoline Ring

被引：4
|
作者：
Babu, Meduri Suresh [1 ]
Rai, Kuria Madhavu Lokanatha [1 ]
机构：
[1] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 17期
关键词：
Nickel chloride; Isoxazoline; Podophyllotoxin; Manganese acetate; DIELS-ALDER REACTION; GAMMA-LACTONES; 1,3-DIPOLAR CYCLOADDITIONS; NITRILE OXIDES; LIGNANS; ROUTE; ANNULATION; OXIDATION; ACETATE; SERIES;
D O I：
10.14233/ajchem.2013.15073
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel synthesis of podophyllotoxin was carried out in four steps. The key step was reduction of isoxazoline ring followed by diazotization and the resultant alkene was treated with Mn(OAc)(3)/CH3COOK to form podophyllotoxin.
引用
收藏
页码：9555 / 9557
页数：3
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