Does the ability to sustain attention underlie symptom severity in schizophrenia?

被引：26

作者：

O'Grada, Cara ^{[1
]}

Barry, Sandra ^{[1
]}

McGlade, Nicola ^{[2
]}

Behan, Caragh ^{[2
]}

Haq, Farhan ^{[2
]}

Hayden, Judy ^{[3
]}

O'Donoghue, Therese ^{[3
]}

Peel, Rosie ^{[3
]}

Morris, Derek W. ^{[3
]}

O'Callaghan, Eadbhard ^{[2
]}

Gill, Michael ^{[3
]}

Corvin, Aiden P. ^{[3
]}

Dinan, Timothy G. ^{[1
]}

Donohoe, Gary ^{[3
]}

机构：

[1] Univ Coll Cork, Dept Psychiat, Cork, Ireland

[2] Univ Coll Dublin, Dublin, Ireland

[3] Univ Dublin Trinity Coll, Neuropsychiat Genet Res Grp, Dublin 2, Ireland

来源：

SCHIZOPHRENIA RESEARCH | 2009年 / 107卷 / 2-3期

基金：

英国惠康基金;

关键词：

Schizophrenia; Cognition; Symptom severity; Attention; Working memory; ANTERIOR CINGULATE CORTEX; PERFORMANCE; DEFICITS; DYSFUNCTION; DIMENSIONS; TASK;

D O I：

10.1016/j.schres.2008.07.013

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

An association between deficits in executive control, particularly inhibitory control, and more severe negative and disorganised symptoms of schizophrenia has been widely reported. The importance of more basic aspects of attention, often referred to as 'vigilant' or 'sustained' attention, to this relationship remains unclear. This study examined the contribution of sustained attention to symptom severity using the Sustained Attention to Response Task (SART) in 69 patients with schizophrenia. We found that negative and disorganised symptom severity scores were correlated with sustained attention, working memory, and psychomotor speed. The ability to sustain attention significantly predicted variance in negative symptom severity but not disorganised symptoms, which were instead predicted by working memory performance. These data suggest that this component of attention at least partly explains variance in negative symptoms. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：319 / 323

页数：5

共 29 条

[11]

Chen WJ, 2000, AM J MED GENET, V97, P52, DOI 10.1002/(SICI)1096-8628(200021)97:1<52::AID-AJMG7>3.0.CO

[12]

2-6

[13] Are deficits in executive sub-processes simply reflecting more general cognitive decline in schizophrenia? [J].