Pharmacological chaperoning of nAChRs: A therapeutic target for Parkinson's disease

被引：49
作者：
Srinivasan, Rahul [1 ]
Henderson, Brandon J. [2 ]
Lester, Henry A. [2 ]
Richards, Christopher I. [3 ]
机构：
[1] Univ Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA
[2] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA
[3] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA
来源：
PHARMACOLOGICAL RESEARCH | 2014年 / 83卷
基金：
美国国家卫生研究院;
关键词：
Pharmacological chaperone; Chaperoning; Nicotine; nAChR; Tobacco; Neuroprotection; Parkinson's disease; Neurodegeneration; Unfolded protein response; Dopaminergic; Endoplasmic reticulum stress; FRET; TIRF; Confocal; ER exit sites; Golgi; Ligand; COPII; COPI; NICOTINIC ACETYLCHOLINE-RECEPTORS; UNFOLDED PROTEIN RESPONSE; INDUCED UP-REGULATION; FAMILIAL AMYLOID POLYNEUROPATHY; ENDOPLASMIC-RETICULUM STRESS; ALPHA-SYNUCLEIN; RAT-BRAIN; CHOLINERGIC-RECEPTOR; ER STRESS; IN-VIVO;
D O I：
10.1016/j.phrs.2014.02.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Chronic exposure to nicotine results in an upregulation of neuronal nicotinic acetylcholine receptors (nAChRs) at the cellular plasma membrane. nAChR upregulation occurs via nicotine-mediated pharmacological receptor chaperoning and is thought to contribute to the addictive properties of tobacco as well as relapse following smoking cessation. At the subcellular level, pharmacological chaperoning by nicotine and nicotinic ligands causes profound changes in the structure and function of the endoplasmic reticulum (ER), ER exit sites, the Golgi apparatus and secretory vesicles of cells. Chaperoning-induced changes in cell physiology exert an overall inhibitory effect on the ER stress/unfolded protein response. Cell autonomous factors such as the repertoire of nAChR subtypes expressed by neurons and the pharmacological properties of nicotinic ligands (full or partial agonist versus competitive antagonist) govern the efficiency of receptor chaperoning and upregulation. Together, these findings are beginning to pave the way for developing pharmacological chaperones to treat Parkinson's disease and nicotine addiction. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：20 / 29
页数：10
相关论文
共 118 条
[1]   Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function [J].
Albuquerque, Edson X. ;
Pereira, Edna F. R. ;
Alkondon, Manickavasagom ;
Rogers, Scott W. .
PHYSIOLOGICAL REVIEWS, 2009, 89 (01) :73-120
[2]   SEQUENTIAL INTERMEDIATES IN THE PATHWAY OF INTERCOMPARTMENTAL TRANSPORT IN A CELL-FREE SYSTEM [J].
BALCH, WE ;
GLICK, BS ;
ROTHMAN, JE .
CELL, 1984, 39 (03) :525-536
[3]  
Belluardo N, 1999, MOL BRAIN RES, V74, P98
[4]  
BENOWITZ NL, 1989, PROG BRAIN RES, V79, P279
[5]   EVIDENCE THAT TOBACCO SMOKING INCREASES THE DENSITY OF (-)-[H-3]NICOTINE BINDING-SITES IN HUMAN-BRAIN [J].
BENWELL, MEM ;
BALFOUR, DJK ;
ANDERSON, JM .
JOURNAL OF NEUROCHEMISTRY, 1988, 50 (04) :1243-1247
[6]   Mapping the Subcellular Distribution of α-Synuclein in Neurons using Genetically Encoded Probes for Correlated Light and Electron Microscopy: Implications for Parkinson's Disease Pathogenesis [J].
Boassa, Daniela ;
Berlanga, Monica L. ;
Yang, Mary Ann ;
Terada, Masako ;
Hu, Junru ;
Bushong, Eric A. ;
Hwang, Minju ;
Masliah, Eliezer ;
George, Julia M. ;
Ellisman, Mark H. .
JOURNAL OF NEUROSCIENCE, 2013, 33 (06) :2605-2615
[7]  
Breese CR, 1997, J COMP NEUROL, V387, P385, DOI 10.1002/(SICI)1096-9861(19971027)387:3<385::AID-CNE5>3.0.CO
[8]  
2-X
[9]   Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers [J].
Brody, Arthur L. ;
Mukhin, Alexey G. ;
La Charite, Jaime ;
Ta, Karen ;
Farahi, Judah ;
Sugar, Catherine A. ;
Mamoun, Michael S. ;
Vellios, Evan ;
Archie, Meena ;
Kozman, Maggie ;
Phuong, Jonathan ;
Arlorio, Franca ;
Mandelkern, Mark A. .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2013, 16 (05) :957-966
[10]   Nicotine Induces the Up-regulation of the α7-Nicotinic Receptor (α7-nAChR) in Human Squamous Cell Lung Cancer Cells via the Sp1/GATA Protein Pathway [J].
Brown, Kathleen C. ;
Perry, Haley E. ;
Lau, Jamie K. ;
Jones, Dennie V. ;
Pulliam, Joseph F. ;
Thornhill, Brent A. ;
Crabtree, Clayton M. ;
Luo, Haitao ;
Chen, Yi. Charlie ;
Dasgupta, Piyali .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (46) :33049-33059
12345678910