Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant

被引：1

作者：

Wei, Duo ^{[1
]}

Bruneau-Voisine, Antoine ^{[1
,2
]}

Valyaev, Dmitry A. ^{[2
]}

Lugan, Noel ^{[2
]}

Sortais, Jean-Baptiste ^{[2
,3
]}

机构：

[1] Univ Rennes, CNRS, UMR 6226, ISCR, F-35000 Rennes, France

[2] Univ Toulouse, CNRS, UPS, LCC, Toulouse, France

[3] Inst Univ France, 1 Rue Descartes, F-75231 Paris 05, France

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 34期

关键词：

PNP PINCER COMPLEXES; PRIMARY ALCOHOLS; SUSTAINABLE SYNTHESIS; AMINE SYNTHESIS; N-METHYLATION; PRE-CATALYST; KETONES; HYDROSILYLATION; METHANOL; EFFICIENT;

D O I：

10.1039/C8CC01787E

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot two-step procedure was developed for the alkylation of amines via reductive amination of aldehydes using molecular dihydrogen as a reductant in the presence of a manganese pyridinyl-phosphine complex as a pre-catalyst. After the initial condensation step, the reduction of imines formed in situ is performed under mild conditions (50-100 degrees C) with 2 mol% of catalyst and 5 mol% of tBuOK under 50 bar of hydrogen. Excellent yields (>90%) were obtained for a large combination of aldehydes and amines (40 examples), including aliphatic aldehydes and amino-alcohols.

引用

页码：4302 / 4305

页数：4

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