Non-invasive Prenatal Testing in Pregnancies Following Assisted Reproduction

被引：2

作者：

Kamath, Vandana ^{[1
]}

Chacko, Mary Purna ^{[1
]}

Kamath, Mohan S. ^{[2
,3
]}

机构：

[1] Christian Med Coll & Hosp, Dept Cytogenet, Vellore 632004, India

[2] Christian Med Coll & Hosp, Dept Reprod Med & Surg, Vellore 632004, India

[3] Christian Med Coll & Hosp, Dept Reprod Med & Surg, Vellore 632004, Tamil Nadu, India

来源：

CURRENT GENOMICS | 2022年 / 23卷 / 05期

关键词：

NIPT; prenatal screening; aneuploidy; ART; pregnancy; assisted reproduction; non-invasive; CELL-FREE DNA; FREE FETAL DNA; IN-VITRO FERTILIZATION; MATERNAL PLASMA DNA; DOWN-SYNDROME; POSITION STATEMENT; UNITED-STATES; ANEUPLOIDY; DIAGNOSIS; TRISOMIES;

D O I：

10.2174/1389202923666220518095758

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the decade since non-invasive prenatal testing (NIPT) was first implemented as a prenatal screening tool, it has gained recognition for its sensitivity and specificity in the detection of common aneuploidies. This review mainly focuses on the emerging role of NIPT in pregnancies following assisted reproductive technology (ART) in the light of current evidence and recommendations. It also deals with the challenges, shortcomings and interpretational difficulties related to NIPT in ART pregnancies, with particular emphasis on twin and vanishing twin pregnancies, which are widely regarded as the Achilles' heel of most pre-natal screening platforms. Future directions for exploration towards improving the performance and extending the scope of NIPT are also addressed.

引用

页码：326 / 336

页数：11

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