Current concepts and controversies in the treatment of alcoholic hepatitis

被引：23
作者：
Rongey, Catherine
Kaplowitz, Neil
机构：
[1] Univ Calif Los Angeles, Robert Wood Johnson Clin Scholars Program, Los Angeles, CA 90024 USA
[2] Univ So Calif, Dept Gastroenterol & Hepatol, Los Angeles, CA 90033 USA
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 43期
关键词：
alcoholic hepatitis; treatment; glucocorticoid; biopsy; scoring system;
D O I：
10.3748/wjg.v12.i43.6909
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The treatment of alcoholic hepatitis remains one of the most debated topics in medicine and a field of continued research. In this review, we discuss the evolution of scoring systems, including the recent development of the Glasgow alcoholic hepatitis score, role of liver biopsy and current treatment interventions. Studies of treatment interventions with glucocorticoids, pentoxifylline, infliximab, s-adenosyl-methionine, and colchicine are reviewed with discussion on quality. Glucocorticoids currently remain the mainstay of treatment for severe alcoholic hepatitis. (c) 2006 The WIG Press. All rights reserved.
引用
收藏
页码：6909 / 6921
页数：13
相关论文
共 131 条
[1]   Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: A double-blind, placebo-controlled trial [J].
Akriviadis, E ;
Botla, R ;
Briggs, W ;
Han, S ;
Reynolds, T ;
Shakil, O .
GASTROENTEROLOGY, 2000, 119 (06) :1637-1648
[2]   FAILURE OF COLCHICINE TO IMPROVE SHORT-TERM SURVIVAL IN PATIENTS WITH ALCOHOLIC HEPATITIS [J].
AKRIVIADIS, EA ;
STEINDEL, H ;
PINTO, PC ;
FONG, TL ;
KANEL, G ;
REYNOLDS, TB ;
GUPTA, S .
GASTROENTEROLOGY, 1990, 99 (03) :811-818
[3]   Combining steroids with enteral nutrition:: a better therapeutic strategy for severe alcoholic hepatitis?: Results of a pilot study [J].
Alvarez, MA ;
Cabré, E ;
Lorenzo-Zuñiga, V ;
Montoliu, S ;
Planas, R ;
Gassull, MA .
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2004, 16 (12) :1375-1380
[4]  
[Anonymous], Remicade (infliximab)
[5]  
[Anonymous], 1964, LIVER PORTAL HYPERTE
[6]   INCREASED PLASMA TUMOR-NECROSIS-FACTOR IN SEVERE ALCOHOLIC HEPATITIS [J].
BIRD, GLA ;
SHERON, N ;
GOKA, AKJ ;
ALEXANDER, GJ ;
WILLIAMS, RS .
ANNALS OF INTERNAL MEDICINE, 1990, 112 (12) :917-920
[7]   ADRENOCORTICOSTEROID THERAPY IN ALCOHOLIC HEPATITIS - PROSPECTIVE, DOUBLE-BLIND RANDOMIZED STUDY [J].
BLITZER, BL ;
MUTCHNICK, MG ;
JOSHI, PH ;
PHILLIPS, MM ;
FESSEL, JM ;
CONN, HO .
AMERICAN JOURNAL OF DIGESTIVE DISEASES, 1977, 22 (06) :477-484
[8]  
BONKOVSKY HL, 1991, AM J GASTROENTEROL, V86, P1200
[9]  
BORIES P, 1987, PRESSE MED, V16, P769
[10]   S-ADENOSYLMETHIONINE PROTECTS AGAINST ACETAMINOPHEN HEPATOTOXICITY IN 2 MOUSE MODELS [J].
BRAY, GP ;
TREDGER, JM ;
WILLIAMS, R .
HEPATOLOGY, 1992, 15 (02) :297-301
12345678910