Emerging therapeutic targets in cancer induced bone disease: A focus on the peripheral type 2 cannabinoid receptor

被引:27
作者
Marino, Silvia [1 ]
Idris, Aymen I. [1 ]
机构
[1] Univ Sheffield, Dept Oncol & Metab, Med Sch, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England
基金
英国医学研究理事会;
关键词
Cnr2; CB2; Osteolysis; Cancer; Bone; Osteoclast; Osteoblast; Osteoporosis; ENDOCANNABINOID SYSTEM; CB2; RECEPTOR; IN-VITRO; OSTEOCLAST FUNCTION; CELL-DEATH; MOLECULAR CHARACTERIZATION; PLANT CANNABINOIDS; INDUCED APOPTOSIS; NEUROPATHIC PAIN; GENE-EXPRESSION;
D O I
10.1016/j.phrs.2017.02.023
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Skeletal complications are a common cause of morbidity in patients with primary bone cancer and bone metastases. The type 2 cannabinoid (Cnr2) receptor is implicated in cancer, bone metabolism and pain perception. Emerging data have uncovered the role of Cnr2 in the regulation of tumour-bone cell interactions and suggest that agents that target Cnr2 in the skeleton have potential efficacy in the reduction of skeletal complications associated with cancer. This review aims to provide an overview of findings relating to the role of Cnr2 receptor in the regulation of skeletal tumour growth, osteolysis and bone pain, and highlights the many unanswered questions and unmet needs. This review argues that development and testing of peripherally-acting, tumour-, Cnr2-selective ligands in preclinical models of metastatic cancer will pave the way for future research that will advance our knowledge about the basic mechanism(s) by which the endocannabinoid system regulate cancer metastasis, stimulate the development of a safer cannabis-based therapy for the treatment of cancer and provide policy makers with powerful tools to assess the science and therapeutic potential of cannabinoid-based therapy. Thus, offering the prospect of identifying selective Cnr2 ligands, as novel, alternative to cannabis herbal extracts for the treatment of advanced cancer patients. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:391 / 403
页数:13
相关论文
共 187 条
  • [1] Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
    Anand, Praveen
    Whiteside, Garth
    Fowler, Christopher J.
    Hohmann, Andrea G.
    [J]. BRAIN RESEARCH REVIEWS, 2009, 60 (01) : 255 - 266
  • [2] The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK
    Andradas, C.
    Caffarel, M. M.
    Perez-Gomez, E.
    Salazar, M.
    Lorente, M.
    Velasco, G.
    Guzman, M.
    Sanchez, C.
    [J]. ONCOGENE, 2011, 30 (02) : 245 - 252
  • [3] The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration
    Ashton, John C.
    Glass, Michelle
    [J]. CURRENT NEUROPHARMACOLOGY, 2007, 5 (02) : 73 - 80
  • [4] CB2: a cannabinoid receptor with an identity crisis
    Atwood, Brady K.
    Mackie, Ken
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2010, 160 (03) : 467 - 479
  • [5] Bab I., 2008, J NEUROENDOCRINOL S1, V20
  • [6] Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: Incidence and risk factors
    Bamias, A
    Kastritis, E
    Bamia, C
    Moulopoulos, LA
    Melakopoulos, L
    Bozas, G
    Koutsoukou, V
    Gika, D
    Anagnostopoulos, A
    Papadimitriou, C
    Terpos, E
    Dimopoulos, MA
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (34) : 8580 - 8587
  • [7] Critical enzymes involved in endocannabinoid metabolism
    Basavarajappa, Balapal S.
    [J]. PROTEIN AND PEPTIDE LETTERS, 2007, 14 (03) : 237 - 246
  • [8] Cannabinoid Receptor 2 Is Critical for the Homing and Retention of Marginal Zone B Lineage Cells and for Efficient T-Independent Immune Responses
    Basu, Sreemanti
    Ray, Avijit
    Dittel, Bonnie N.
    [J]. JOURNAL OF IMMUNOLOGY, 2011, 187 (11) : 5720 - 5732
  • [9] Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease
    Basu, Sreemanti
    Dittel, Bonnie N.
    [J]. IMMUNOLOGIC RESEARCH, 2011, 51 (01) : 26 - 38
  • [10] Endocannabinoids in endocrine and related tumours
    Bifulco, Maurizio
    Malfitano, Anna Maria
    Pisanti, Simona
    Laezza, Chiara
    [J]. ENDOCRINE-RELATED CANCER, 2008, 15 (02) : 391 - 408