Emerging therapeutic targets in cancer induced bone disease: A focus on the peripheral type 2 cannabinoid receptor
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作者:
Marino, Silvia
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Univ Sheffield, Dept Oncol & Metab, Med Sch, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, EnglandUniv Sheffield, Dept Oncol & Metab, Med Sch, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England
Marino, Silvia
[1
]
Idris, Aymen I.
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Univ Sheffield, Dept Oncol & Metab, Med Sch, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, EnglandUniv Sheffield, Dept Oncol & Metab, Med Sch, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England
Idris, Aymen I.
[1
]
机构:
[1] Univ Sheffield, Dept Oncol & Metab, Med Sch, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England
Skeletal complications are a common cause of morbidity in patients with primary bone cancer and bone metastases. The type 2 cannabinoid (Cnr2) receptor is implicated in cancer, bone metabolism and pain perception. Emerging data have uncovered the role of Cnr2 in the regulation of tumour-bone cell interactions and suggest that agents that target Cnr2 in the skeleton have potential efficacy in the reduction of skeletal complications associated with cancer. This review aims to provide an overview of findings relating to the role of Cnr2 receptor in the regulation of skeletal tumour growth, osteolysis and bone pain, and highlights the many unanswered questions and unmet needs. This review argues that development and testing of peripherally-acting, tumour-, Cnr2-selective ligands in preclinical models of metastatic cancer will pave the way for future research that will advance our knowledge about the basic mechanism(s) by which the endocannabinoid system regulate cancer metastasis, stimulate the development of a safer cannabis-based therapy for the treatment of cancer and provide policy makers with powerful tools to assess the science and therapeutic potential of cannabinoid-based therapy. Thus, offering the prospect of identifying selective Cnr2 ligands, as novel, alternative to cannabis herbal extracts for the treatment of advanced cancer patients. (C) 2017 Elsevier Ltd. All rights reserved.
机构:
Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA
Indiana Univ, Gill Ctr, Bloomington, IN 47405 USA
Univ Washington, Program Neurobiol & Behav, Seattle, WA 98195 USAIndiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA
Atwood, Brady K.
Mackie, Ken
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Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA
Indiana Univ, Gill Ctr, Bloomington, IN 47405 USAIndiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA
机构:
BloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI 53201 USA
Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USABloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI 53201 USA
Basu, Sreemanti
Ray, Avijit
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BloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI 53201 USABloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI 53201 USA
Ray, Avijit
Dittel, Bonnie N.
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BloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI 53201 USA
Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USABloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI 53201 USA
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Blood Ctr SE Wisconsin Inc, Blood Res Inst, Milwaukee, WI 53233 USA
Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USABlood Ctr SE Wisconsin Inc, Blood Res Inst, Milwaukee, WI 53233 USA
Basu, Sreemanti
Dittel, Bonnie N.
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机构:
Blood Ctr SE Wisconsin Inc, Blood Res Inst, Milwaukee, WI 53233 USA
Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USABlood Ctr SE Wisconsin Inc, Blood Res Inst, Milwaukee, WI 53233 USA
机构:
Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA
Indiana Univ, Gill Ctr, Bloomington, IN 47405 USA
Univ Washington, Program Neurobiol & Behav, Seattle, WA 98195 USAIndiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA
Atwood, Brady K.
Mackie, Ken
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA
Indiana Univ, Gill Ctr, Bloomington, IN 47405 USAIndiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA
机构:
BloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI 53201 USA
Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USABloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI 53201 USA
Basu, Sreemanti
Ray, Avijit
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h-index: 0
机构:
BloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI 53201 USABloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI 53201 USA
Ray, Avijit
Dittel, Bonnie N.
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机构:
BloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI 53201 USA
Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USABloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI 53201 USA
机构:
Blood Ctr SE Wisconsin Inc, Blood Res Inst, Milwaukee, WI 53233 USA
Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USABlood Ctr SE Wisconsin Inc, Blood Res Inst, Milwaukee, WI 53233 USA
Basu, Sreemanti
Dittel, Bonnie N.
论文数: 0引用数: 0
h-index: 0
机构:
Blood Ctr SE Wisconsin Inc, Blood Res Inst, Milwaukee, WI 53233 USA
Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USABlood Ctr SE Wisconsin Inc, Blood Res Inst, Milwaukee, WI 53233 USA