Different neoadjuvant therapies for locally advanced rectal cancer: A systematic review and network meta-analysis

被引：7

作者：

Petrelli, Fausto ^{[1
,5
]}

Trevisan, Francesca ^{[2
]}

Tomasello, Gianluca ^{[3
]}

De Stefani, Agostina ^{[2
]}

Viti, Matteo ^{[4
]}

Garrone, Ornella ^{[3
]}

Luciani, Andrea ^{[1
]}

Ghidini, Michele ^{[3
]}

机构：

[1] ASST Bergamo Ovest, Oncol Unit, Treviglio, BG, Italy

[2] ASST Bergamo Ovest, Radiotherapy Unit, Treviglio, BG, Italy

[3] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Med Oncol Unit, Milan, Italy

[4] ASST Bergamo Ovest, Surg Oncol Unit, Treviglio, BG, Italy

[5] ASST Bergamo Ovest, Med Sci Dept, Oncol Unit, Piazzale Osped 1, I-24047 Treviglio, BG, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2022年 / 180卷

关键词：

Rectal cancer; Neoadjuvant; Chemoradiotherapy; Meta; -analysis; Survival; TOTAL MESORECTAL EXCISION; PREOPERATIVE CHEMORADIOTHERAPY; CONCOMITANT CHEMORADIOTHERAPY; OPEN-LABEL; PHASE-II; CHEMOTHERAPY; RADIOTHERAPY; CAPECITABINE; OXALIPLATIN; MULTICENTER;

D O I：

10.1016/j.critrevonc.2022.103853

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One of the historical standard of care for locally advanced rectal adenocarcinoma (LARC) is neoadjuvant fluoropyrimidine-based chemoradiotherapy (FP-based CTRT) followed 6-8 weeks later by surgery. The incor-poration of further chemotherapy cycles (CT) before or after CTRT (total neoadjuvant therapy) resulted in better outcomes than CTRT alone. Therefore, we performed a network meta-analysis (NMA) to compare the relative efficacy of different neoadjuvant treatments for LARC. Fixed-or random-effects models were fit using a Bayesian approach to NMA. Between-group comparisons were estimated using hazard ratios (HRs) or risk ratios (RRs) with 95 % credible intervals (95 % CrIs). A total of 23 randomized clinical trials were included. In Bayesian com-parisons. FOLFIRINOX followed by capecitabine-based CTRT resulted in better OS than other regimens, including the previous standard, and ranked as the best regimen with a probability of 87 %. This NMA confirms that adopting total neoadjuvant therapy improves outcome compared to other preoperative strategies, including FP -based CTRT.

引用

页数：4

共 15 条

[1] Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial [J].

Bahadoer, Renu R. ;

Dijkstra, Esmee A. ;

van Etten, Boudewijn ;

Marijnen, Corrie A. M. ;

Putter, Hein ;

Kranenbarg, Elma Meershoek-Klein ;

Roodvoets, Annet G. H. ;

Nagtegaal, Iris D. ;

Beets-Tan, Regina G. H. ;

Blomqvist, Lennart K. ;

Fokstuen, Tone ;

ten Tije, Albert J. ;

Capdevila, Jaume ;

Hendriks, Mathijs P. ;

Edhemovic, Ibrahim ;

Cervantes, Andres ;

Nilsson, Per J. ;

Glimelius, Bengt ;

van de Velde, Cornelis J. H. ;

Hospers, Geke A. P. .

LANCET ONCOLOGY, 2021, 22 (01) :29-42

[2] Rectal Cancer, Version 2.2018 Clinical Practice Guidelines in Oncology [J].

Benson, Al B., III ;

Venook, Alan P. ;

Al-Hawary, Mahmoud M. ;

Cederquist, Lynette ;

Chen, Yi-Jen ;

Ciombor, Kristen K. ;

Cohen, Stacey ;

Cooper, Harry S. ;

Deming, Dustin ;

Engstrom, Paul F. ;

Grem, Jean L. ;

Grothey, Axel ;

Hochster, Howard S. ;

Hoffe, Sarah ;

Hunt, Steven ;

Kamel, Ahmed ;

Kirilcuk, Natalie ;

Krishnamurthi, Smitha ;

Messersmith, Wells A. ;

Meyerhardt, Jeffrey ;

Mulcahy, Mary F. ;

Murphy, James D. ;

Nurkin, Steven ;

Saltz, Leonard ;

Sharma, Sunil ;

Shibata, David ;

Skibber, John M. ;

Sofocleous, Constantinos T. ;

Stoffel, Elena M. ;

Stotsky-Himelfarb, Eden ;

Willett, Christopher G. ;

Wuthrick, Evan ;

Gregory, Kristina M. ;

Gurski, Lisa ;

Freedman-Cass, Deborah A. .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2018, 16 (07) :874-901

[3] Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer [J].

Cercek, Andrea ;

Roxburgh, Campbell S. D. ;

Strombom, Paul ;

Smith, J. Joshua ;

Temple, Larissa K. F. ;

Nash, Garrett M. ;

Guillem, Jose G. ;

Paty, Philip B. ;

Yaeger, Rona ;

Stadler, Zsofia K. ;

Seier, Kenneth ;

Gonen, Mithat ;

Segal, Neil H. ;

Reidy, Diane L. ;

Varghese, Anna ;

Shia, Jinru ;

Vakiani, Efsevia ;

Wu, Abraham J. ;

Crane, Christopher H. ;

Gollub, Marc J. ;

Garcia-Aguilar, Julio ;

Saltz, Leonard B. ;

Weiser, Martin R. .

JAMA ONCOLOGY, 2018, 4 (06)

[4] Long-course preoperative chemoradiation versus 5 x 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study [J].

Cisel, B. ;

Pietrzak, L. ;

Michalski, W. ;

Wyrwicz, L. ;

Rutkowski, A. ;

Kosakowska, E. ;

Cencelewicz, A. ;

Spalek, M. ;

Polkowski, W. ;

Jankiewicz, M. ;

Stylinski, R. ;

Bebenek, M. ;

Kapturkiewicz, B. ;

Maciejczyk, A. ;

Sadowski, J. ;

Zygulska, J. ;

Zegarski, W. ;

Jankowski, M. ;

Las-Jankowska, M. ;

Toczko, Z. ;

Zelazowska-Omiotek, U. ;

Kepka, L. ;

Socha, J. ;

Wasilewska-Tesluk, E. ;

Markiewicz, W. ;

Kladny, J. ;

Majewski, A. ;

Kapuscinski, W. ;

Suwinski, R. ;

Bujko, K. .

ANNALS OF ONCOLOGY, 2019, 30 (08) :1298-1303

[5] Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23) : a multicentre, randomised, open-label, phase 3 trial [J].

Conroy, Thierry ;

Bosset, Jean-Francois ;

Etienne, Pierre-Luc ;

Rio, Emmanuel ;

Francois, Eric ;

Mesgouez-Nebout, Nathalie ;

Vendrely, Veronique ;

Artignan, Xavier ;

Bouche, Olivier ;

Gargot, Dany ;

Boige, Valerie ;

Bonichon-Lamichhane, Nathalie ;

Louvet, Christophe ;

Morand, Clotilde ;

de la Fouchardiere, Christelle ;

Lamfichekh, Najib ;

Juzyna, Beata ;

Jouffroy-Zeller, Claire ;

Rullier, Eric ;

Marchal, Frederic ;

Gourgou, Sophie ;

Castan, Florence ;

Borg, Christophe .

LANCET ONCOLOGY, 2021, 22 (05) :702-715

[6] Neoadjuvant Modified FOLFOX6 With or Without Radiation Versus Fluorouracil Plus Radiation for Locally Advanced Rectal Cancer: Final Results of the Chinese FOWARC Trial [J].

Deng, Yanhong ;

Chi, Pan ;

Lan, Ping ;

Wang, Lei ;

Chen, Weiqing ;

Cui, Long ;

Chen, Daoda ;

Cao, Jie ;

Wei, Hongbo ;

Peng, Xiang ;

Huang, Zonghai ;

Cai, Guanfu ;

Zhao, Ren ;

Huang, Zhongcheng ;

Xu, Lin ;

Zhou, Hongfeng ;

Wei, Yisheng ;

Zhang, Hao ;

Zheng, Jian ;

Huang, Yan ;

Zhou, Zhiyang ;

Cai, Yue ;

Kang, Liang ;

Huang, Meijin ;

Wu, Xiaojian ;

Peng, Junsheng ;

Ren, Donglin ;

Wang, Jianping .

JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (34) :3223-+

[7] Multicenter Randomized Phase II Clinical Trial Comparing Neoadjuvant Oxaliplatin, Capecitabine, and Preoperative Radiotherapy With or Without Cetuximab Followed by Total Mesorectal Excision in Patients With High-Risk Rectal Cancer (EXPERT-C) [J].

Dewdney, Alice ;

Cunningham, David ;

Tabernero, Josep ;

Capdevila, Jaume ;

Glimelius, Bengt ;

Cervantes, Andres ;

Tait, Diana ;

Brown, Gina ;

Wotherspoon, Andrew ;

de Castro, David Gonzalez ;

Chua, Yu Jo ;

Wong, Rachel ;

Barbachano, Yolanda ;

Oates, Jacqueline ;

Chau, Ian .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (14) :1620-1627

[8] Effect of Aflibercept Plus Modified FOLFOX6 Induction Chemotherapy Before Standard Chemoradiotherapy and Surgery in Patients With High-Risk Rectal Adenocarcinoma The GEMCAD 1402 Randomized Clinical Trial [J].

Fernandez-Martos, Carlos ;

Pericay, Carles ;

Losa, Ferran ;

Garcia-Carbonero, Rocio ;

Layos, Laura ;

Rodriguez-Salas, Nuria ;

Martin-Richard, Marta ;

Alonso-Orduna, Vicente ;

Vera, Ruth ;

Gallego, Javier ;

Capdevila, Jaume ;

Salud, Antonieta ;

Nogue, Miquel ;

Maurel, Joan ;

Guash, Inmaculada ;

Montagut, Clara ;

Lopez, Carlos ;

Macias, Ismael ;

Jain, Rakesh K. ;

Garcia-Albeniz, Xabier .

JAMA ONCOLOGY, 2019, 5 (11) :1566-1573

[9] Phase II, Randomized Study of Concomitant Chemoradiotherapy Followed by Surgery and Adjuvant Capecitabine Plus Oxaliplatin (CAPOX) Compared With Induction CAPOX Followed by Concomitant Chemoradiotherapy and Surgery in Magnetic Resonance Imaging-Defined, Locally Advanced Rectal Cancer: Grupo Cancer de Recto 3 Study [J].

Fernandez-Martos, Carlos ;

Pericay, Carles ;

Aparicio, Jorge ;

Salud, Antonieta ;

Safont, MariaJose ;

Massuti, Bertomeu ;

Vera, Ruth ;

Escudero, Pilar ;

Maurel, Joan ;

Marcuello, Eugenio ;

Luis Mengual, Jose ;

Saigi, Eugenio ;

Estevan, Rafael ;

Mira, Moises ;

Polo, Sonia ;

Hernandez, Ana ;

Gallen, Manuel ;

Arias, Fernando ;

Serra, Javier ;

Alonso, Vicente .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (05) :859-865

[10] Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer Long-term Results of the CAO/ARO/AIO-12 Randomized Clinical Trial [J].

Fokas, Emmanouil ;

Schlenska-Lange, Anke ;

Polat, Buelent ;

Klautke, Gunther ;

Grabenbauer, Gerhard G. ;

Fietkau, Rainer ;

Kuhnt, Thomas ;

Staib, Ludger ;

Brunner, Thomas ;

Grosu, Anca-Ligia ;

Kirste, Simon ;

Jacobasch, Lutz ;

Allgaeuer, Michael ;

Flentje, Michael ;

Germer, Christoph-Thomas ;

Gruetzmann, Robert ;

Hildebrandt, Guido ;

Schwarzbach, Matthias ;

Bechstein, Wolf O. ;

Suelberg, Heiko ;

Friede, Tim ;

Gaedcke, Jochen ;

Ghadimi, Michael ;

Hofheinz, Ralf-Dieter ;

Roedel, Claus .

JAMA ONCOLOGY, 2022, 8 (01)

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