Identification of differentially expressed genes in adipose tissue of min pig and large white pig using RNA-seq

被引：3

作者：

Wang, W. T. ^{[1
,2
]}

Zhang, D. J. ^{[2
]}

Liu, Z. G. ^{[2
]}

Peng, F. G. ^{[2
]}

Wang, L. ^{[2
]}

Fu, B. ^{[2
]}

Wu, S. H. ^{[2
]}

Li, Z. Q. ^{[2
]}

Guo, Z. H. ^{[2
]}

Liu, D. ^{[1
,2
]}

机构：

[1] Northeast Forestry Univ, Coll Wildlife Resource, Harbin, Heilongjiang, Peoples R China

[2] Heilongjiang Acad Agr Sci, Inst Anim Husb, Harbin, Heilongjiang, Peoples R China

来源：

ACTA AGRICULTURAE SCANDINAVICA SECTION A-ANIMAL SCIENCE | 2018年 / 68卷 / 02期

基金：

中国国家自然科学基金;

关键词：

RNA-seq; min pig; large white pig; fat; differentially expressed genes (DEGs); MITOCHONDRIAL TRANSCRIPTION FACTOR; POLYMORPHISMS; ASSOCIATION; PROMOTER; MUTATION; SOX12; TBK1;

D O I：

10.1080/09064702.2019.1611912

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Min pigs and Large White pigs are two breeds that vary significantly in thickness of adipose tissue. In this study, transcriptome profiling was used to examine the fat tissues of both breeds. Min pig compared to Large White pig, 523 DEGs were down-regulated, and 112 DEGs were up-regulated. The DEGs were significantly enriched in biological process of oxidoreductase activity; helicase activity and others. In cellular component, DEGs were enriched in intracellular. In molecular function, DEGs were enriched in cytoskeletal protein binding and ion binding. Although there were many DEGs between Min pigs and Large White pigs, no significant pathway was enriched surprisingly. ATP6V0A4, TAP2, FGFBP1, PHEROA and GLYATL2 were expressed significantly higher in Large White pigs. These results suggest that the gene expression pattern in the back fat tissue was different between Large White pigs and Min pigs.

引用

页码：73 / 80

页数：8

共 35 条

[1] SOX12 and NRSN2 Are Candidate Genes for 20p13 Subtelomeric Deletions Associated with Developmental Delay [J].

An, Yu ;

Amr, Sami S. ;

Torres, Alcy ;

Weissman, Laura ;

Raffalli, Peter ;

Cox, Gerald ;

Sheng, Xiaoming ;

Lip, Va ;

Bi, Weimin ;

Patel, Ankita ;

Stankiewicz, Pawel ;

Wu, Bai-Lin ;

Shen, Yiping .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2013, 162 (08) :832-840

[2] Human Surrogate Models of Histaminergic and Non-histaminergic Itch [J].

Andersen, Hjalte H. ;

Elberling, Jesper ;

Arendt-Nielsen, Lars .

ACTA DERMATO-VENEREOLOGICA, 2015, 95 (07) :771-777

[3] A Genetic Risk Score Is Associated with Weight Loss Following Roux-en Y Gastric Bypass Surgery [J].

Bandstein, Marcus ;

Voisin, Sarah ;

Nilsson, Emil K. ;

Schultes, Bernd ;

Ernst, Barbara ;

Thurnheer, Martin ;

Benedict, Christian ;

Mwinyi, Jessica ;

Schioth, Helgi B. .

OBESITY SURGERY, 2016, 26 (09) :2183-2189

[4] Cardiac excitation-contraction coupling [J].

Bers, DM .

NATURE, 2002, 415 (6868) :198-205

[5] Mitochondrial transcription factor A regulation of mitochondrial degeneration in experimental diabetic neuropathy [J].

Chandrasekaran, Krish ;

Anjaneyulu, Muragundla ;

Inoue, Tatsuya ;

Choi, Joungil ;

Sagi, Avinash Rao ;

Chen, Chen ;

Ide, Tamomi ;

Russell, James W. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2015, 309 (02) :E132-E141

[6] Pyruvate dehydrogenase kinase 4 (PDK4) could be involved in a regulatory role in apoptosis and a link between apoptosis and insulin resistance [J].

Dlamini, Zodwa ;

Ntlabati, Patricia ;

Mbita, Zukile ;

Shoba-Zikhali, Lungile .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2015, 98 (03) :574-584

[7] Role of Toll-like receptors in diabetic renal lesions in a miniature pig model [J].

Feng, Yuanyuan ;

Yang, Shulin ;

Ma, Yuxiang ;

Bai, Xue-Yuan ;

Chen, Xiangmei .

SCIENCE ADVANCES, 2015, 1 (05)

[8] Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort [J].

Gijselinck, Ilse ;

Van Mossevelde, Sara ;

van der Zee, Julie ;

Sieben, Anne ;

Philtjens, Stephanie ;

Heeman, Bavo ;

Engelborghs, Sebastiaan ;

Vandenbulcke, Mathieu ;

De Baets, Greet ;

Baumer, Veerle ;

Cuijt, Ivy ;

Van den Broeck, Marleen ;

Peeters, Karin ;

Mattheijssens, Maria ;

Rousseau, Frederic ;

Vandenberghe, Rik ;

De Jonghe, Peter ;

Cras, Patrick ;

De Deyn, Peter P. ;

Martin, Jean-Jacques ;

Cruts, Marc ;

Van Broeckhoven, Christine .

NEUROLOGY, 2015, 85 (24) :2116-2125

[9] NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice [J].

Hofstetter, Amelia R. ;

De La Cruz, Juan A. ;

Cao, Weiping ;

Patel, Jenish ;

Belser, Jessica A. ;

McCoy, James ;

Liepkalns, Justine S. ;

Amoah, Samuel ;

Cheng, Guangjie ;

Ranjan, Priya ;

Diebold, Becky A. ;

Shieh, Wun-Ju ;

Zaki, Sherif ;

Katz, Jacqueline M. ;

Sambhara, Suryaprakash ;

Lambeth, J. David ;

Gangappa, Shivaprakash .

PLOS ONE, 2016, 11 (02)

[10] Sox12, a direct target of FoxQ1, promotes hepatocellular carcinoma metastasis through up-regulating Twist1 and FGFBP1 [J].

Huang, Wenjie ;

Chen, Zhangqian ;

Shang, Xin ;

Tian, Dean ;

Wang, Daowen ;

Wu, Kaichun ;

Fan, Daiming ;

Xia, Limin .

HEPATOLOGY, 2015, 61 (06) :1920-1933

← 1 2 3 4 →