Giving blood: a new role for CD40 in tumorigenesis

被引：30

作者：

Bergmann, Stephan ^{[1
]}

Pandolfi, Pier Paolo ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, Dept Pathol, New York, NY 10021 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2006年 / 203卷 / 11期

关键词：

D O I：

10.1084/jem.20061754

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD40 was initially identified as a receptor expressed by B cells that is crucial for inducing an effective adaptive immune response. CD40 was subsequently shown to be expressed by endothelial cells and to promote angiogenesis. New data now show that in tumor-prone transgenic mice, CD40-mediated neovas-cularization is essential for early stage tumorigenicity. This suggests, at least in this mouse model, that CD40 has an important role in the angiogenic process that is coupled to carcinogenesis, a finding that could lead to novel therapeutic opportunities.

引用

页码：2409 / 2412

页数：4

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