miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease

被引：24

作者：

Eken, Suzanne M. ^{[1
]}

Christersdottir, Tinna ^{[2
]}

Winski, Greg ^{[1
]}

Sangsuwan, Traimate ^{[3
]}

Jin, Hong ^{[1
]}

Chernogubova, Ekaterina ^{[1
]}

Pirault, John ^{[4
]}

Sun, Changyan ^{[1
]}

Simon, Nancy ^{[1
]}

Winter, Hanna ^{[5
,6
]}

Backlund, Alexandra ^{[1
]}

Haghdoost, Siamak ^{[3
,7
]}

Hansson, Goran K. ^{[1
]}

Halle, Martin ^{[2
,8
]}

Maegdefessel, Lars ^{[1
,5
,6
]}

机构：

[1] Karolinska Inst, Dept Med, Cardiovasc Med Unit, Stockholm, Sweden

[2] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden

[3] Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden

[4] Univ Lorraine, INSERM UMR S1116, Vandoeuvre Les Nancy, France

[5] Tech Univ Munich, Dept Vasc & Endovasc Surg, Munich, Germany

[6] German Ctr Cardiovasc Res DZHK, Partner Site Munich, Munich, Germany

[7] Univ Caen Normandie, LARIA CIMAP, Caen, France

[8] Karolinska Univ Hosp, Dept Reconstruct Plast Surg, Stockholm, Sweden

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2019年 / 4卷 / 01期

基金：

瑞典研究理事会; 欧洲研究理事会;

关键词：

arteriosclerosis; inflammation; microRNA; radiotherapy; FREE-FLAP RECONSTRUCTION; CARDIOVASCULAR-DISEASE; CANCER-TREATMENT; INNATE IMMUNITY; RADIATION; HEAD; COMPLICATIONS; MICRORNAS; RECOGNITION; PENTRAXINS;

D O I：

10.1016/j.jacbts.2018.10.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

As a consequence of the success of present-day cancer treatment, radiotherapy-induced vascular disease is emerging. This disease is caused by chronic inflammatory activation and is likely orchestrated in part by microRNAs. In irradiated versus nonirradiated conduit arteries from patients receiving microvascular free tissue transfer reconstructions, irradiation resulted in down-regulation of miR-29b and up-regulation of miR-146b. miR-29b affected inflammation and adverse wound healing through its targets pentraxin-3 and dipeptidylpeptidase 4. In vitro and in vivo, we showed that miR-29b overexpression therapy, through inhibition of pentraxin-3 and dipeptidyl-peptidase 4, could dampen the vascular inflammatory response. (C) 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：72 / 82

页数：11

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