Ecklonia cava extract suppresses the high-affinity IgE receptor, FcεRI expression

被引：42
|
作者：
Shim, Sun-Yup [2 ]
Quang-To, Le [1 ]
Lee, Sang-Hoon [1 ]
Kim, Se-Kwon [1 ,3 ]
机构：
[1] Pukyong Natl Univ, Dept Chem, Pusan 608737, South Korea
[2] Pukyong Natl Univ, Inst Marine Life Sci, Pusan 608737, South Korea
[3] Pukyong Natl Univ, Marine Bioproc Res Ctr, Pusan 608737, South Korea
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2009年 / 47卷 / 03期
关键词：
Ecklonia cava; Fc epsilon RI; IgE; Histamine; BROWN ALGA; CELL-LINE; B-CELLS; PHLOROTANNINS; INDUCTION; MONOCYTES; HISTAMINE; DUST;
D O I：
10.1016/j.fct.2008.12.012
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Basophils and mast cells express Fc epsilon RI, a high-affinity receptor for IgE, on the cell surface and act as effector cells in allergic reactions. In this study, we investigated the inhibitory effect of Ecklonia cava (EC) methanolic extract on the expression of Fc epsilon RI in human basophilic KU812F cells, Flow cytometric analysis revealed that EC extract caused a concentration-dependent reduction in the cell surface expression of Fc epsilon RI. The extract was also capable of reducing the binding between IgE or serum IgE and cell surface Fc epsilon RI. RT-PCR analysis revealed that EC extract reduced the mRNA expression of total cellular Fc epsilon RI alpha-chain. Moreover, data obtained by fluorescence spectrophotometry showed that the extract inhibited the Fc epsilon RI-mediated release of histamine in a concentration-dependent manner. These results suggest that EC extract may exert its anti-allergic activity through negative-regulation of Fc epsilon RI expression and a decrease in histamine release. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：555 / 560
页数：6
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