Immunosuppressive environment in response to androgen deprivation treatment in prostate cancer

被引：10

作者：

Qin, Caipeng ^{[1
]}

Wang, Jing ^{[2
]}

Du, Yiqing ^{[1
]}

Xu, Tao ^{[1
]}

机构：

[1] Peking Univ Peoples Hosp, Dept Urol, Beijing, Peoples R China

[2] Univ Sci & Technol China, Univ Sci & Technol China USTC, Dept Urol Oncol, Div Life Sci & Med,Affiliated Hosp 1, Hefei, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷

关键词：

prostate cancer; single cell RNAseq; ADT; immune microenvironment; immunotherapy; SEX-DIFFERENCES; THERAPY; CASTRATION; CELLS;

D O I：

10.3389/fendo.2022.1055826

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

RationaleTo invest the role of androgen deprivation therapy (ADT) on the tumor immune microenvironment of prostate cancer. MethodsHere we have profiled the transcriptomes of 19,227 single cells from 4 prostate tumors, including two cases who received ADT. To validated the single-cell analysis we use another group of patients receiving neoadjuvant ADT. ResultsAfter receiving ADT treatment, the killing effect of prostate cancer immune cells on tumors is weakened, the interaction between immune cells and tumor cells is weakened, and the proportion of immunosuppressive cells Myeloid-derived suppressor cell (MDSC) and Regulatory T cells (Treg) cells increases. ConclusionsOur results highlight that ADT induces immunosuppressive in the prostate tumor microenvironment. These data have important implications for combining ADT with immunotherapy.

引用

页数：11

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