Amino acid sensing by mTORC1, a new pathway involved in metabolism and cancer

被引：0

作者：

Giorgetti-Peraldi, Sophie ^{[1
]}

Peraldi, Pascal ^{[2
]}

Dumas, Karine ^{[1
]}

Pastor, Faustine ^{[1
]}

Tanti, Jean-Francois ^{[1
]}

机构：

[1] Univ Nice Sophia Antipolis, Equipe Physiopathol Cellulaire & Mol Obes & Diabe, C3M, Inserm U1065, Nice, France

[2] Univ Nice Sophia Antipolis, UFR Med, Inserm U1091, CNRS UMR 7277, F-06108 Nice, France

来源：

CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION | 2016年 / 20卷 / 10期

关键词：

mTORC1; Amino acid; Cancer; Metabolism; TUMOR-SUPPRESSOR; RAG GTPASES; CELL-GROWTH; COMPLEX; ACTIVATION; GAP;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

mTORC1 plays a crucial role to adapt metabolism to environmental conditions, such as nutrients and growth factors. mTORC1 activation in response to growth factors and amino acids requires distinct signaling pathways. Mutations affecting amino acids sensing are involved in pathologies such as cancer, primary immunodeficience syndrome and Birt-Hogg-Dube syndrome

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收藏

页码：300 / 305

页数：6

相关论文

共 23 条

[1] Regulation of mTORC1 by amino acids [J].

Bar-Peled, Liron ;

Sabatini, David M. .

TRENDS IN CELL BIOLOGY, 2014, 24 (07) :400-406

[2] A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1 [J].

Bar-Peled, Liron ;

Chantranupong, Lynne ;

Cherniack, Andrew D. ;

Chen, Walter W. ;

Ottina, Kathleen A. ;

Grabiner, Brian C. ;

Spear, Eric D. ;

Carter, Scott L. ;

Meyerson, Matthew ;

Sabatini, David M. .

SCIENCE, 2013, 340 (6136) :1100-1106

[3] Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels tomTORC1 [J].

Bar-Peled, Liron ;

Schweitzer, Lawrence D. ;

Zoncu, Roberto ;

Sabatini, David M. .

CELL, 2012, 150 (06) :1196-1208

[4] A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14 [J].

Bohn, Georg ;

Allroth, Anna ;

Brandes, Gudrun ;

Thiel, Jens ;

Glocker, Erik ;

Schaffer, Alejandro A. ;

Rathinam, Chozhavendan ;

Taub, Nicole ;

Teis, David ;

Zeidler, Cornelia ;

Dewey, Ricardo A. ;

Geffers, Robert ;

Buer, Jan ;

Huber, Lukas A. ;

Welte, Karl ;

Grimbacher, Bodo ;

Klein, Christoph .

NATURE MEDICINE, 2007, 13 (01) :38-45

[5] The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway [J].

Chantranupong, Lynne ;

Scaria, Sonia M. ;

Saxton, Robert A. ;

Gygi, Melanie P. ;

Shen, Kuang ;

Wyant, Gregory A. ;

Wang, Tim ;

Harper, J. Wade ;

Gygi, Steven P. ;

Sabatini, David M. .

CELL, 2016, 165 (01) :153-164

[6] The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1 [J].

Chantranupong, Lynne ;

Wolfson, Rachel L. ;

Orozco, Jose M. ;

Saxton, Robert A. ;

Scaria, Sonia M. ;

Bar-Peled, Liron ;

Spooner, Eric ;

Isasa, Marta ;

Gygi, Steven P. ;

Sabatini, David M. .

CELL REPORTS, 2014, 9 (01) :1-8

[7] Regulation of mTORC1 by PI3K signaling [J].

Dibble, Christian C. ;

Cantley, Lewis C. .

TRENDS IN CELL BIOLOGY, 2015, 25 (09) :545-555

[8] Signal integration by mTORC1 coordinates nutrient input with biosynthetic output [J].

Dibble, Christian C. ;

Manning, Brendan D. .

NATURE CELL BIOLOGY, 2013, 15 (06) :555-564

[9] Amino Acid Sensing bymTORC1: Intracellular Transporters Mark the Spot [J].

Goberdhan, Deborah C. I. ;

Wilson, Clive ;

Harris, Adrian L. .

CELL METABOLISM, 2016, 23 (04) :580-589

[10] Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2 [J].

Hasumi, Yukiko ;

Baba, Masaya ;

Ajima, Rieko ;

Hasumi, Hisashi ;

Valera, Vladimir A. ;

Klein, Mara E. ;

Haines, Diana C. ;

Merino, Maria J. ;

Hong, Seung-Beom ;

Yamaguchi, Terry P. ;

Schmidt, Laura S. ;

Linehan, W. Marston .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (44) :18722-18727