Efficacy of Artemisinin-Based Combination Therapy for Treatment of Persons with Uncomplicated Plasmodium falciparum Malaria in West Sumba District, East Nusa Tenggara Province, Indonesia, and Genotypic Profiles of the Parasite

被引：16

作者：

Asih, Puji B. S. ^{[1
]}

Dewi, Rita M. ^{[2
]}

Tuti, Sekar ^{[2
]}

Sadikin, Mohamad ^{[3
]}

Sumarto, Wajio ^{[4
]}

Sinaga, Bonar ^{[4
]}

van der Ven, Andre J. A. M. ^{[5
]}

Sauerwein, Robert W. ^{[5
]}

Sayfruddin, Din ^{[1
]}

机构：

[1] Eijkman Inst Mol Biol, Jakarta 10430, Indonesia

[2] Natl Inst Hlth Res & Dev, Minist Hlth, Jakarta, Indonesia

[3] Univ Indonesia, Dept Biochem, Fac Med, Jakarta, Indonesia

[4] W Sumba Dist Hlth Dept, Waikabubak, Easst Nusa Teng, Indonesia

[5] Radboud Univ Nijmegen Med Ctr, NL-6500 HB Nijmegen, Netherlands

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2009年 / 80卷 / 06期

关键词：

DIHYDROPTEROATE-SYNTHETASE GENES; SULFADOXINE-PYRIMETHAMINE; DIHYDROFOLATE-REDUCTASE; ARTESUNATE-AMODIAQUINE; CLINICAL-EFFICACY; RESISTANCE; CHLOROQUINE; ALLELES; PROPHYLAXIS; SENSITIVITY;

D O I：

10.4269/ajtmh.2009.80.914

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Reports on treatment failures associated with the use of first- and second-fine antimalarial drugs chloroquine and sulfadoxine-pyrimethamine have recently increased in many parts of Indonesia. The present study evaluated artemisinin-based combination therapy for treatment of persons with uncomplicated Plasmodium falciparum malaria in West Sumba District, East Nusa Tenggara Province. A total of 103 persons 1-57 years of age were enrolled, given Standard artesunate-amodiaquine therapy, and followed-up for 28 days. All persons clinically recovered, but two persons were again parasitemic on day 7. This finding indicated that these two persons had recurrent parasitemias on days 21 and 28. Molecular analyses suggested both recurrences were caused by reinfections. There were no severe adverse events, but complaints of gastrointestinal upset, nausea and vomiting, and headache linked to therapy occurred among 9.7%, 5.8% and 5.8% of the persons, respectively. Artesunate-amodiaquine proved efficacious therapy for treatment of persons with uncomplicated P. falcipparum malaria at one site in eastern Indonesia but it may have tolerability problems that merit further investigation.

引用

页码：914 / 918

页数：5

共 27 条

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