Cyclin-dependent kinases: inhibition and substrate recognition

被引：94
|
作者：
Endicott, JA
Noble, MEM
Tucker, JA
机构：
[1] Lab Mol Biophys, Oxford OX1 3QU, England
[2] Univ Oxford, Dept Biochem, Oxford Ctr Mol Sci, Oxford OX1 3QU, England
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1999年 / 9卷 / 06期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/S0959-440X(99)00038-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Four unresolved issues of cyclin-dependent kinase (CDK) regulation have been addressed by structural studies this year - the mechanism of CDK inhibition by members of the INK4 family of CDK inhibitors, consensus substrate sequence recognition by CDKs, the role of the cyclin subunit in substrate recognition and the structural mechanism underlying CDK inhibition by phosphorylation.
引用
收藏
页码：738 / 744
页数：7
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