Structures and functions of mitochondrial ABC transporters

被引：55

作者：

Schaedler, Theresia A. ^{[1
]}

Faust, Belinda ^{[2
]}

Shintre, Chitra A. ^{[2
]}

Carpenter, Elisabeth P. ^{[2
]}

Srinivasan, Vasundara ^{[3
,4
]}

van Veen, Hendrik W. ^{[5
]}

Balk, Janneke ^{[6
,7
]}

机构：

[1] Rothamsted Res, Dept Biol Chem & Crop Protect, Harpenden AL5 2JQ, Herts, England

[2] Univ Oxford, Nuffield Dept Clin Med, Struct Genom Consortium, Oxford OX3 7DQ, England

[3] LOEWE Ctr Synthet Microbiol SYNMIKRO, D-35043 Marburg, Germany

[4] Univ Marburg, D-35043 Marburg, Germany

[5] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1PD, England

[6] John Innes Ctr, Norwich NR4 7UH, Norfolk, England

[7] Univ E Anglia, Norwich NR4 7UH, Norfolk, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2015年 / 43卷

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

ATP-binding cassette (ABC) transporter; glutathione; haem; iron; mitochondria; oxidative stress; BINDING CASSETTE TRANSPORTER; CYTOCHROME-C BIOGENESIS; IRON-SULFUR PROTEINS; ETHYLMALONIC ENCEPHALOPATHY; SACCHAROMYCES-CEREVISIAE; HEME-BIOSYNTHESIS; P-GLYCOPROTEIN; IN-VIVO; ARABIDOPSIS; MEMBRANE;

D O I：

10.1042/BST20150118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A small number of physiologically important ATP-binding cassette (ABC) transporters are found in mitochondria. Most are half transporters of the B group forming homodimers and their topology suggests they function as exporters. The results of mutant studies point towards involvement in iron cofactor biosynthesis. In particular, ABC subfamily B member 7 (ABCB7) and its homologues in yeast and plants are required for iron-sulfur (Fe-S) cluster biosynthesis outside of the mitochondria, whereas ABCB10 is involved in haem biosynthesis. They also play a role in preventing oxidative stress. Mutations in ABCB6 and ABCB7 have been linked to human disease. Recent crystal structures of yeast Atm1 and human ABCB10 have been key to identifying substrate-binding sites and transport mechanisms. Combined with in vitro and in vivo studies, progress is being made to find the physiological substrates of the different mitochondrial ABC transporters.

引用

页码：943 / 951

页数：9

共 61 条

[1] Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding [J].

Aller, Stephen G. ;

Yu, Jodie ;

Ward, Andrew ;

Weng, Yue ;

Chittaboina, Srinivas ;

Zhuo, Rupeng ;

Harrell, Patina M. ;

Trinh, Yenphuong T. ;

Zhang, Qinghai ;

Urbatsch, Ina L. ;

Chang, Geoffrey .

SCIENCE, 2009, 323 (5922) :1718-1722

[2] Targeting of the mitochondrial membrane proteins to the cell surface for functional studies [J].

Ardehali, H ;

Xue, T ;

Dong, P ;

Machamer, C .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 338 (02) :1143-1151

[3] Iron Cofactor Assembly in Plants [J].

Balk, Janneke ;

Schaedler, Theresia A. .

ANNUAL REVIEW OF PLANT BIOLOGY, VOL 65, 2014, 65 :125-+

[4] ATP-Binding Cassette B10 Regulates Early Steps of Heme Synthesis [J].

Bayeva, Marina ;

Khechaduri, Arineh ;

Wu, Rongxue ;

Burke, Michael A. ;

Wasserstrom, J. Andrew ;

Singh, Neha ;

Liesa, Marc ;

Shirihai, Orian S. ;

Langer, Nathaniel B. ;

Paw, Barry H. ;

Ardehali, Hossein .

CIRCULATION RESEARCH, 2013, 113 (03) :279-287

[5] An Allelic Mutant Series of ATM3 Reveals Its Key Role in the Biogenesis of Cytosolic Iron-Sulfur Proteins in Arabidopsis [J].

Bernard, Delphine G. ;

Cheng, Youfa ;

Zhao, Yunde ;

Balk, Janneke .

PLANT PHYSIOLOGY, 2009, 151 (02) :590-602

[6] Functional characterization of AtATM1, AtATM2, and AtATM3, a subfamily of Arabidopsis half-molecule ATP-binding cassette transporters implicated in iron homeostasis [J].

Chen, Sixue ;

Sánchez-Fernández, Rocío ;

Lyver, Elise R. ;

Dancis, Andrew ;

Rea, Philip A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (29) :21561-21571

[7] Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis [J].

Chen, Wen ;

Dailey, Harry A. ;

Paw, Barry H. .

BLOOD, 2010, 116 (04) :628-630

[8] Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria [J].

Chen, Wen ;

Paradkar, Prasad N. ;

Li, Liangtao ;

Pierce, Eric L. ;

Langer, Nathaniel B. ;

Takahashi-Makise, Naoko ;

Hyde, Brigham B. ;

Shirihai, Orian S. ;

Ward, Diane M. ;

Kaplan, Jerry ;

Paw, Barry H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (38) :16263-16268

[9] MDL1 is a high copy suppressor of ATM1:: Evidence for a role in resistance to oxidative stress [J].

Chloupková, M ;

LeBard, LS ;

Koeller, DM .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 331 (01) :155-165

[10] Loss of ATP hydrolysis activity by CcmAB results in loss of c-type cytochrome synthesis and incomplete processing of CcmE [J].

Christensen, Olaf ;

Harvat, Edgar M. ;

Thony-Meyer, Linda ;

Ferguson, Stuart J. ;

Stevens, Julie M. .

FEBS JOURNAL, 2007, 274 (09) :2322-2332

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