Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system

被引：27

作者：

Zawislak, Agnieszka A. ^{[2
]}

McCluggage, William G. ^{[3
]}

Donnelly, Ryan F. ^{[4
]}

Maxwell, Peter ^{[3
]}

Price, John H. ^{[2
]}

Dobbs, Stephen P. ^{[2
]}

McClelland, H. Raymond ^{[2
]}

Woolfson, A. David ^{[4
]}

Mccarron, Paul A. ^{[1
]}

机构：

[1] Univ Ulster, Dept Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland

[2] Belfast City Hosp, Dept Gynaecol, Belfast BT9 7AD, Antrim, North Ireland

[3] Royal Victoria Hosp, Dept Pathol, Belfast, Antrim, North Ireland

[4] Queens Univ Belfast, Ctr Med Biol, Sch Pharm, Belfast BT9 7BL, Antrim, North Ireland

来源：

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE | 2009年 / 25卷 / 02期

关键词：

bioadhesive patch; photodynamic therapy; squamous hyperplasia; vulval lichen sclerosus; 5-AMINOLEVULINIC ACID; THERAPY;

D O I：

10.1111/j.1600-0781.2009.00410.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

This study evaluated the clinical and histopathological responses of vulval lichen sclerosus (LS) and squamous hyperplasia (SH) to photodynamic therapy (PDT). A novel bioadhesive patch containing aminolevulinic acid (ALA) at a dose of (38 mg/cm(2)) was used to treat 10 patients before irradiation with light of 630 nm. Clinical, histopathological and pathological responses to treatment were assessed at 6 weeks post-treatment. After 17 cycles of PDT, six patients reported significant symptomatic relief and no cutaneous photosensitivity. Histopathological differences were not demonstrated, but statistically significant induction of apoptosis was seen. It can be concluded that ALA-PDT patch-based formulation is pragmatic and primarily offers symptomatic management of vulval LS and SH.

引用

页码：111 / 113

页数：3

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