A look inside the diabetic brain: Contributors to diabetes-induced brain aging

被引：149

作者：

Wrighten, Shayna A. ^{[1
]}

Piroli, Gerardo G. ^{[1
]}

Grillo, Claudia A. ^{[1
]}

Reagan, Lawrence P. ^{[1
]}

机构：

[1] Univ S Carolina, Sch Med, Dept Pharmacol Physiol & Neurosci, Columbia, SC 29208 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2009年 / 1792卷 / 05期

关键词：

Hippocampus insulin; Glucose; Cognition; Alzheimer's disease; Obesity; LONG-TERM POTENTIATION; HIPPOCAMPAL SYNAPTIC PLASTICITY; GLYCATION END-PRODUCTS; CENTRAL-NERVOUS-SYSTEM; WHITE-MATTER LESIONS; MILD COGNITIVE IMPAIRMENT; OBESE ZUCKER RATS; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; SPATIAL MEMORY;

D O I：

10.1016/j.bbadis.2008.10.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Central nervous system (CNS) complications resulting from diabetes is a problem that is gaining more acceptance and attention. Recent evidence suggests morphological, electrophysiological and cognitive changes, often observed in the hippocampus, in diabetic individuals. Many of the CNS changes observed in diabetic patients and animal models of diabetes are reminiscent of the changes seen in normal aging. The central commonalities between diabetes-induced and age-related CNS changes have led to the theory of advanced brain aging in diabetic patients. This review summarizes the findings of the literature as they relate to the relationship between diabetes and dementia and discusses some of the potential contributors to diabetes-induced CNS impairments. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：444 / 453

页数：10

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