Immediate, Complete, and Sustained Inhibition of C5 with ALXN1210 Reduces Complement- Mediated Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Interim Analysis of a Dose-Escalation Study

被引：6

作者：

Lee, Jong-Wook ^{[1
,2
]}

Bachman, Eric Scott ^{[3
]}

Aguzzi, Rasha ^{[4
]}

Jang, Jun Ho ^{[5
]}

Kim, Jin Seok ^{[6
]}

Rottinghaus, Scott T. ^{[7
]}

Shafner, Lori ^{[7
]}

Szer, Jeff ^{[8
]}

机构：

[1] Canc Res Inst, Div Hematol, Catholic Blood & Marrow Transplantat Ctr, Seoul, South Korea

[2] Catholic Univ Korea, St Marys Hosp, Coll Med, Seoul, South Korea

[3] Alexion Pharmaceut Inc, Translat Med, Cambridge, MA USA

[4] Alexion Pharmaceut Inc, Biostat, Cambridge, MA USA

[5] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Seoul, South Korea

[6] Yonsei Univ, Div Hematol, Dept Internal Med, Coll Med, Seoul, South Korea

[7] Alex Pharmaceut Inc, Global Dev, New Haven, CT USA

[8] Royal Melbourne Hosp, Clin Haematol, Parkville, Vic, Australia

来源：

关键词：

D O I：

10.1182/blood.V128.22.2428.2428

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

2428

引用

页数：6