Isolation and characterization of diterpene glycosides from Siegesbeckia pubescens

被引：14
|
作者：
Wang, Jianbin [1 ]
Xie, Kehui [1 ]
Duan, Hongquan [2 ,3 ]
Wang, Yi [1 ]
Ma, He [4 ]
Fu, Hongzheng [1 ]
机构：
[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[2] Tianjin Med Univ, Tianjin Key Lab Technol Enabling Dev Clin Therape, Sch Pharm, Tianjin 300070, Peoples R China
[3] Tianjin Med Univ, Res Ctr Basic Med Sci, Tianjin 300070, Peoples R China
[4] Shandong Acad Pharmaceut Sci, Jinan 250101, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Diterpenoid glycosides; Siegesbeckia pubescens; MB-MDA-231 breast cancer cells; Chemokine epithelial growth factor; NF-KAPPA-B; COLLAGEN-INDUCED ARTHRITIS; ENT-PIMARANE DITERPENOIDS; ORIENTALIS; EXPRESSION; INOS;
D O I：
10.1016/j.bmcl.2017.02.051
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five new diterpenoid glycosides, siegesides A-E (1-5), along with the known compound darutoside (6) were isolated and characterized from the ethanol extract of Siegesbeckia pubescens. The structural elucidation of the isolates was accomplished by extensive HRESIMS and NMR analysis. Compounds 1 and 2 are epimers of 6. All isolates were evaluated for their inhibition on the migration of MB-MDA-231 breast cancer cells induced by the chemokine epithelial growth factor, and compound 2 showed superior inhibitory activities in comparison with the positive control drug with IC50 value of 0.27 mu M. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1815 / 1819
页数：5
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