Cellular therapies in organ transplantation

被引：18

作者：

Hoogduijn, Martin J. ^{[1
]}

Issa, Fadi ^{[2
]}

Casiraghi, Federica ^{[3
]}

Reinders, Marlies E. J. ^{[1
]}

机构：

[1] Erasmus MC, Dept Internal Med, Erasmus Med Ctr, Nephrol & Transplantat, Rotterdam, Netherlands

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Transplantat Res & Immunol Grp, Oxford, England

[3] Ist Ric Farmacol Mario Negri IRCCS, Bergamo, Italy

来源：

TRANSPLANT INTERNATIONAL | 2021年 / 34卷 / 02期

基金：

英国医学研究理事会;

关键词：

cell therapy; immunomodulation; mesenchymal stromal cells; regeneration; regulatory macrophages; regulatory T-cells; MESENCHYMAL STROMAL CELLS; REGULATORY T-CELLS; STEM-CELLS; KIDNEY-TRANSPLANTATION; RENAL-TRANSPLANTATION; ALLOGRAFT SURVIVAL; EXTRACELLULAR VESICLES; PRETRANSPLANT INFUSION; MACROPHAGES CONTROL; INDUCTION THERAPY;

D O I：

10.1111/tri.13789

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Cellular therapy is a promising tool for improving the outcome of organ transplantation. Various cell types with different immunoregulatory and regenerative properties may find application for specific transplant rejection or injury-related indications. The current era is crucial for the development of cellular therapies. Preclinical models have demonstrated the feasibility of efficacious cell therapy in transplantation, early clinical trials have shown safety of several of these therapies, and the first steps towards efficacy studies in humans have been made. In this review, we address the current state of the art of cellular therapies in clinical transplantation and discuss monitoring tools and endpoints for these studies.

引用

页码：233 / 244

页数：12

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