What Are Clinically Relevant Levels of Cellular and Biomolecular Analytes?

被引：122

作者：

Kelley, Shana O. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Toronto, Fac Arts & Sci, Dept Chem, Toronto, ON M5S 3M2, Canada

[2] Univ Toronto, Leslie Dan Fac Pharm, Dept Pharmaceut Sci, Toronto, ON M5S 3M2, Canada

[3] Univ Toronto, Fac Med, Inst Biomat & Biomed Engn, Toronto, ON M5S 3M2, Canada

[4] Univ Toronto, Fac Med, Dept Biochem, Toronto, ON M5S 3M2, Canada

来源：

ACS SENSORS | 2017年 / 2卷 / 02期

关键词：

bioanalysis; DNA detection; protein detection; clinical samples; infectious disease; cancer; VIRAL LOAD; REAL-TIME; ADULT PATIENTS; NUCLEIC-ACIDS; PANDEMIC H1N1; TUMOR-CELLS; ZIKA VIRUS; ASSAY; CANCER; DIAGNOSIS;

D O I：

10.1021/acssensors.6b00691

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ultimate goal of developing sensors for biomolecular analytes is to offer new tools for the analysis of clinical specimens for biomarkers of disease. It is thus important to understand the types of samples that are routinely used in the clinic for specific indications, and what the typical levels of relevant analytes are in these specimens. This Sensor Issues article summarizes information concerning levels of target molecules and cells that are of interest for the development of new diagnostics for infectious disease and cancer. Having this information in hand helps better define the "needle-in-a-haystack" challenge associated with developing robust sensors with the needed levels of sensitivity and specificity.

引用

页码：193 / 197

页数：5

共 46 条

[1] OPINION Challenges in circulating tumour cell research [J].

Alix-Panabieres, Catherine ;

Pantel, Klaus .

NATURE REVIEWS CANCER, 2014, 14 (09) :623-631

[2] Global Burden of Hepatitis C: Considerations for Healthcare Providers in the United States [J].

Averhoff, Francisco M. ;

Glass, Nancy ;

Holtzman, Deborah .

CLINICAL INFECTIOUS DISEASES, 2012, 55 :S10-S15

[3] Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy [J].

Bagshaw, Sean M. ;

Lapinsky, Stephen ;

Dial, Sandra ;

Arabi, Yaseen ;

Dodek, Peter ;

Wood, Gordon ;

Ellis, Paul ;

Guzman, Jorge ;

Marshall, John ;

Parrillo, Joseph E. ;

Skrobik, Yoanna ;

Kumar, Anand .

INTENSIVE CARE MEDICINE, 2009, 35 (05) :871-881

[4] A Multisite Assessment of the Quantitative Capabilities of the Xpert MTB/RIF Assay [J].

Blakemore, Robert ;

Nabeta, Pamela ;

Davidow, Amy L. ;

Vadwai, Viral ;

Tahirli, Rasim ;

Munsamy, Vanisha ;

Nicol, Mark ;

Jones, Martin ;

Persing, David H. ;

Hillemann, Doris ;

Ruesch-Gerdes, Sabine ;

Leisegang, Felicity ;

Zamudio, Carlos ;

Rodrigues, Camilla ;

Boehme, Catharina C. ;

Perkins, Mark D. ;

Alland, David .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 184 (09) :1076-1084

[5] Wound microbiology and associated approaches to wound management [J].

Bowler, PG ;

Duerden, BI ;

Armstrong, DG .

CLINICAL MICROBIOLOGY REVIEWS, 2001, 14 (02) :244-+

[6] Active surveillance for prostate cancer: a narrative review of clinical guidelines [J].

Bruinsma, Sophie M. ;

Bangma, Chris H. ;

Carroll, Peter R. ;

Leapman, Michael S. ;

Rannikko, Antti ;

Petrides, Neophytos ;

Weerakoon, Mahesha ;

Bokhorst, Leonard P. ;

Roobol, Monique J. .

NATURE REVIEWS UROLOGY, 2016, 13 (03) :151-167

[7] Circulating Disease Biomarker Detection in Complex Matrices: Real-Time, In Situ Measurements of DNA/miRNA Hybridization via Electrochemical Impedance Spectroscopy [J].

Capaldo, Pietro ;

Alfarano, Serena Rosa ;

Ianeselli, Luca ;

Dal Zilio, Simone ;

Bosco, Alessandro ;

Parisse, Pietro ;

Casalis, Loredana .

ACS SENSORS, 2016, 1 (08) :1003-1010

[8] A Perspective on Cancer Cell Metastasis [J].

Chaffer, Christine L. ;

Weinberg, Robert A. .

SCIENCE, 2011, 331 (6024) :1559-1564

[9] PSA Detection with Femtomolar Sensitivity and a Broad Dynamic Range Using SERS Nanoprobes and an Area-Scanning Method [J].

Chang, Hyejin ;

Kang, Homan ;

Ko, Eunbyeol ;

Jun, Bong-Hyun ;

Lee, Ho-Young ;

Lee, Yoon-Sik ;

Jeang, Dae Hong .

ACS SENSORS, 2016, 1 (06) :645-649

[10] Simple and Versatile Detection of Viruses Using Anodized Alumina Membranes [J].

Chaturvedi, Pavan ;

Rodriguez, Stacy D. ;

Vlassiouk, Ivan ;

Hansen, Immo A. ;

Smirnov, Sergei N. .

ACS SENSORS, 2016, 1 (05) :488-492

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